Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 5/20 | 0.33 |
| ▸ | HTR1A | P08908 | 4/20 | 0.33 |
| ▸ | HTR2B | P41595 | 4/20 | 0.33 |
| ▸ | HTR6 | P50406 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3716594 | 0.99 | CHEK1 (0.38) | CHEK1CHEK2PLK4PAK4CCNC | |
| SCHEMBL4178231 | 0.79 | CHEK1 (0.58) | CHEK1CHEK2CCNCCDK8CDK19 | |
| Hydrochloric Acid SCHEMBL3714080 | 0.78 | CHEK1 (0.57) | CHEK1CHEK2CCNCCDK8CDK19 | |
| Hydrochloric Acid SCHEMBL3716314 | 0.78 | CHEK1 (0.57) | CHEK1CHEK2CCNCCDK8CDK19 | |
| SCHEMBL3739355 | 0.77 | JAK1 (0.42) | MAPT | |
| SCHEMBL4164895 | 0.76 | CHEK1 (0.54) | CHEK1CHEK2PLK4PAK4ADRB2 | |
| SCHEMBL3736680 | 0.76 | AKT2 (0.41) | CHEK1CHEK2PLK4PAK4ADRB2 | |
| Hydrochloric Acid SCHEMBL3720255 | 0.75 | PLK4 (0.44) | CHEK1CHEK2PLK4PAK4ADRB2 | |
| Hydrochloric Acid SCHEMBL3718343 | 0.75 | CHEK1 (0.53) | CHEK1CHEK2PLK4PAK4ADRB2 | |
| Hydrochloric Acid SCHEMBL3723324 | 0.75 | ADRB2 (0.53) | CHEK1CHEK2PLK4PAK4ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372842-B2 | Pyrazolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2013-02-12 | — | — | US | disclosed |
| EP-2242757-B1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20100280043-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280043-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | CHEK2, CHEK1, BUB1B | CHEK1 2/4885CHEK2 1/4885PLK4 102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.