Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 11/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PLAUR | Q03405 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3741834 | 0.90 | PTGES (0.55) | PTGESPDPK1HPGDKDM4ENPC1 | |
| SCHEMBL3745904 | 0.88 | PDPK1 (0.52) | PTGESPDPK1HPGDKDM4ENPC1 | |
| SCHEMBL1052466 | 0.82 | NPBWR1 (0.44) | PTGESPDPK1HPGDKDM4ENPC1 | |
| SCHEMBL1054128 | 0.82 | HPGD (0.43) | PDPK1HPGDKDM4ENPC1ALDH1A1 | |
| SCHEMBL3732815 | 0.81 | NPC1 (0.53) | PTGESPDPK1HPGDKDM4ENPC1 | |
| SCHEMBL3739404 | 0.81 | ADORA3 (0.59) | PDPK1HPGDKDM4ENPC1ALDH1A1 | |
| SCHEMBL3745620 | 0.78 | PDGFRB (0.43) | PDPK1HPGDKDM4ENPC1ALDH1A1 | |
| SCHEMBL6382926 | 0.78 | HPGD (0.47) | PTGESPDPK1HPGDKDM4ENPC1 | |
| SCHEMBL3731117 | 0.78 | RAB9A (0.62) | HPGDKDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL17968230 | 0.77 | SMN1; SMN2 (0.67) | PTGESPDPK1HPGDKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825132-B2 | Inhibition of FGFR3 and treatment of multiple myeloma | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| CN-1483028-A | Quinolinone derivatives as tyrosine kinase inhibitors | ϣ | 2004-03-17 | — | — | CN | disclosed |