Iosarcol

Iosarcol

SCHEMBL373108

CC(=O)Nc1c(I)c(NC(C)=O)c(I)c(C(=O)N(C)CC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1I

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.55
LMNA P02545 5/20 0.39
TOP1 P11387 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iosarcol SCHEMBL29473413 1.00 SMN1; SMN2 (0.55) SMN1; SMN2LMNATOP1
SCHEMBL11526230 0.86 SMN1; SMN2 (0.64) SMN1; SMN2LMNA
SCHEMBL11467420 0.84 SMN1; SMN2 (0.53) SMN1; SMN2LMNA
SCHEMBL8911300 0.83 SMN1; SMN2 (0.49) SMN1; SMN2LMNA
Iosarcol SCHEMBL1301899 0.81 LMNA (0.74) SMN1; SMN2LMNA
SCHEMBL619808 0.76 LMNA (0.60) SMN1; SMN2LMNA
SCHEMBL10879331 0.76 LMNA (0.50) SMN1; SMN2LMNA
SCHEMBL11346172 0.75 SMN1; SMN2 (0.45) SMN1; SMN2LMNA
SCHEMBL11340513 0.75 LMNA (0.46) SMN1; SMN2LMNA
Mannitol SCHEMBL8510041 0.74 SMN1; SMN2 (0.60) SMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 480 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11903835-B2 Demineralized bone fiber composition for use in minimally invasive surgery THERACELL, LLC (US) 2024-02-20 US claimed
US-10994998-B2 Setting of hardenable bone substitute BONE SUPPORT AB (SE) 2021-05-04 US claimed
US-20200188122-A1 DEMINERALIZED BONE FIBER COMPOSITION FOR USE IN MINIMALLY INVASIVE SURGERY ARTERIOCYTE MEDICAL SYSTEMS, INC. 2020-06-18 US claimed
EP-3274003-B1 BIPHASIC CERAMIC BONE SUBSTITUTE BONE SUPPORT AB (SE) 2019-07-17 EP claimed
WO-2019048697-A1 MACRO- AND MICROPOROUS COMPOSITE CRYOGEL BIOMATERIAL FOR USE IN BONE REGENERATION BONE SUPPORT AB (SE) 2019-03-14 WO claimed
US-20180257939-A1 SETTING OF HARDENABLE BONE SUBSTITUTE BONE SUPPORT AB (SE) 2018-09-13 US claimed
EP-2185272-B1 REMOVAL OF SILICA FROM WATER SOLUBLE COMPOUNDS BY NANOFILTRATION AND REVERSE PHASE CHROMATOGRAPHY LIEBEL FLARSHEIM CO LLC (US) 2018-05-02 EP claimed
EP-2958603-B1 IMPROVED SETTING OF HARDENABLE BONE SUBSTITUTE BONE SUPPORT AB (SE) 2018-03-28 EP claimed
US-20180055969-A1 BIPHASIC CERAMIC BONE SUBSTITUTE BONE SUPPORT AB (SE) 2018-03-01 US claimed
CN-107660153-A Biphase ceramics bone substitute 骨支撑股份公司 2018-02-02 CN claimed
EP-0703790-B1 IODINATED PARAMAGNETIC CHELATES, AND THEIR USE AS CONTRAST AGENTS BRACCO SPA (IT) 2000-08-16 EP claimed
WO-1999062570-A1 METHOD FOR MANUFACTURING A POWDER COMPONENT FOR CEMENT FOR MEDICAL USE, USE OF SUCH POWDER COMPONENT AND SUCH POWDER COMPONENT BONE SUPPORT AB (SE) 1999-12-09 WO claimed
US-5660814-A Iodinated paramagnetic chelates, and their use as contrast agents DIBRA S.P.A. (IT) 1997-08-26 US claimed
EP-0703790-A1 IODINATED PARAMAGNETIC CHELATES, AND THEIR USE AS CONTRAST AGENTS BRACCO S.p.A. (IT) 1996-04-03 EP claimed
WO-1994027644-A1 IODINATED PARAMAGNETIC CHELATES, AND THEIR USE AS CONTRAST AGENTS BRACCO S.P.A. (IT) 1994-12-08 WO claimed
EP-0414288-B1 Contrast media NYCOMED IMAGING AS (NO) 1994-03-23 EP claimed
US-5242683-A Gastrointestinal tract, side effect reduction NYCOMED IMAGING AS (NO) 1993-09-07 US claimed
EP-0473729-A1 CONTRAST MEDIA NYCOMED AS (NO) 1992-03-11 EP claimed
EP-0414288-A1 Contrast media NYCOMED IMAGING AS (NO) 1991-02-27 EP claimed
WO-1991001149-A1 CONTRAST MEDIA NYCOMED AS (NO) 1991-02-07 WO claimed