SCHEMBL373404

SCHEMBL373404

C=C(C)C(=O)OCCCc1ccc(N=Nc2cc(C(=O)c3ccccc3)c(O)cc2O)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 4/20 0.38
PPARA Q07869 1/20 0.38
LMNA P02545 3/20 0.36
HPGD P15428 3/20 0.36
KDM4E B2RXH2 1/20 0.36
CYP3A4 P08684 1/20 0.36
MAPT P10636 1/20 0.36
RECQL P46063 1/20 0.36
HSD17B10 Q99714 1/20 0.36
HTT P42858 2/20 0.36
POLB P06746 1/20 0.36
APEX1 P27695 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
PRKCG P05129 3/20 0.36
PRKCB P05771 3/20 0.36
PRKCA P17252 3/20 0.36
PRKCE Q02156 3/20 0.36
PRKCD Q05655 3/20 0.36
PRKCH P24723 2/20 0.35
PRKACA P17612 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16693261 0.94 L3MBTL1 (0.39) PPARGPPARALMNAHPGDKDM4E
SCHEMBL373648 0.94 L3MBTL1 (0.39) PPARGPPARALMNAHPGDKDM4E
SCHEMBL3258579 0.90 CHRNB2 (0.34) PPARGPPARALMNAHPGDHTT
SCHEMBL3258581 0.90 CHRNB2 (0.34) PPARGPPARALMNAHPGDHTT
SCHEMBL373543 0.88 HPGD (0.41) PPARGLMNAHPGDKDM4ECYP3A4
SCHEMBL7178326 0.88 HPGD (0.41) PPARGLMNAHPGDKDM4ECYP3A4
SCHEMBL13269909 0.88 PPARA (0.34) PPARGPPARALMNAKDM4EHTT
SCHEMBL13269910 0.88 PPARA (0.34) PPARGPPARALMNAKDM4EHTT
SCHEMBL7599491 0.87 PPARG (0.41) PPARGPPARALMNACYP3A4MAPT
SCHEMBL3196968 0.87 PPARA (0.34) PPARGPPARALMNAHPGDKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023068316-A1 MATERIAL FOR SOFT CONTACT LENS HAVING CONTRAST IMPROVEMENT FUNCTION 興和株式会社 2023-04-27 WO disclosed
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-3822296-A1 POLYMER MATERIAL Menicon Co., Ltd. (JP) 2021-05-19 EP disclosed
EP-3086162-B1 OCULAR LENS MENICON CO LTD (JP) 2019-04-17 EP disclosed
US-20180356561-A1 GEL, GEL MANUFACTURING METHOD, LENS, CONTACT LENS SURFACE MODIFIER, POLYMERIZABLE COMPOSITION, AND POLYMER JSR CORPORATION (JP) 2018-12-13 US disclosed
EP-3086163-B1 POLYSILOXANE-BASED MACROMONOMER FOR USE IN OCULAR LENS AND OCULAR LENS USING SAME MENICON CO LTD (JP) 2018-11-14 EP disclosed
EP-2857459-B1 STABLE POLYMERIZABLE UV-ABSORBING COLORANT FOR INTRAOCULAR LENS KOWA CO (JP) 2017-12-27 EP disclosed
US-9657131-B2 Ophthalmic lens MENICON CO., LTD. (JP) 2017-05-23 US disclosed
US-9650473-B2 Polysiloxane-based macromonomer for ophthalmic lens and ophthalmic lens using the same MENICON CO., LTD. (JP) 2017-05-16 US disclosed
EP-2330161-B1 DYE COMPOSITION FOR OPHTHALMIC LENS, METHOD FOR PRODUCING COLORED OPHTHALMIC LENS USING THE SAME AND COLORED OPHTHALMIC LENS MENICON CO LTD (JP) 2017-01-25 EP disclosed
US-5416180-A Fluorine containing (meth)acrylate polymers MENICON CO., LTD. (JP) 1995-05-16 US disclosed
US-5416132-A Acrylamide modified acrylate modified polysiloxanes MENICON CO., LTD. (JP) 1995-05-16 US disclosed
EP-0381005-B1 Ocular lens material MENICON CO LTD (JP) 1995-01-11 EP disclosed
US-5346946-A Polysiloxane macromonomer MENICON CO., LTD (JP) 1994-09-13 US disclosed
EP-0600269-A2 Soft ocular lens material Menicon Co., Ltd. (JP) 1994-06-08 EP disclosed
EP-0584826-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0584764-A1 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0578087-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-01-12 EP disclosed
US-5041511-A Vinyl benzene acrylate or methacrylate crosslinking agent MENICON CO., LTD. (JP) 1991-08-20 US disclosed
US-4954586-A COPOLYMER OF A FLUORINE CONTAINING (METH)ACRYLATE, AN ALKYL (METH)ACRYLATE, A POLYSILOXANE AND A URETHANE CONTAINING POLYSILOXANE MENICON CO., LTD (JP) 1990-09-04 US disclosed