Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433770 | 0.84 | TSHR (0.42) | HSD11B1TDP1SMN1; SMN2 | |
| SCHEMBL12493556 | 0.76 | KDM4E (0.38) | KMT2AKDM4EMAPTATMCYP2D6 | |
| SCHEMBL12289214 | 0.72 | KMT2A (0.34) | KMT2AKDM4EMAPTATMCYP2D6 | |
| SCHEMBL27189678 | 0.71 | GAA (0.33) | KDM4E | |
| SCHEMBL29967623 | 0.71 | KMT2A (0.41) | KMT2AKDM4EMAPTATMCYP2D6 | |
| SCHEMBL31269742 | 0.69 | GPR119 (0.36) | KMT2AKDM4EMAPTATMCYP2D6 | |
| SCHEMBL3675205 | 0.69 | HSD11B1 (0.38) | KMT2AKDM4EMAPTATMCYP2D6 | |
| SCHEMBL2150720 | 0.67 | LMNA (0.37) | KMT2AMEN1L3MBTL1SMN1; SMN2 | |
| SCHEMBL29967605 | 0.67 | KMT2A (0.41) | KMT2AKDM4EMAPTATMCYP2D6 | |
| SCHEMBL30243980 | 0.67 | KDM4E (0.33) | KMT2AKDM4EMAPTATMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139861-A1 | BENZIMIDAZOLES WITH A HETERO SPIRO-DECANE RESIDUE AS NPY-Y5 ANTAGONISTS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008129007-A1 | BENZIMIDAZOLES WITH A HETERO SPIRO-DECANE RESIDUE AS NPY-Y5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |