Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6748393 | 0.79 | RAB9A (0.34) | RAB9A | |
| SCHEMBL14113217 | 0.79 | MAPT (0.44) | RAB9AKDM4ENPC1ALDH1A1GAA | |
| SCHEMBL30892582 | 0.78 | PDE10A (0.39) | ALDH1A1HSD17B10 | |
| SCHEMBL5547638 | 0.72 | KDM4E (0.33) | RAB9AKDM4ENPC1ALDH1A1GLA | |
| SCHEMBL15004601 | 0.72 | RAB9A (0.38) | RAB9AKDM4ENPC1ALDH1A1GLA | |
| SCHEMBL3727714 | 0.71 | — | — | |
| SCHEMBL3738135 | 0.71 | RAB9A (0.41) | RAB9AKDM4ENPC1ALDH1A1GAA | |
| SCHEMBL13050204 | 0.68 | RAB9A (0.33) | RAB9AKDM4ENPC1ALDH1A1GLA | |
| SCHEMBL3702111 | 0.68 | ALDH1A1 (0.38) | RAB9AKDM4ENPC1ALDH1A1GLA | |
| SCHEMBL21045066 | 0.67 | RAB9A (0.49) | RAB9AKDM4ENPC1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100280010-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2010-11-04 | — | — | US | disclosed |
| EP-1919872-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1799671-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-10 | — | — | EP | disclosed |
| EP-1784185-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1984376-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-04-08 | — | — | EP | disclosed |
| EP-1984376-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-10-29 | — | — | EP | disclosed |
| US-20080234318-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-25 | — | — | US | disclosed |
| US-20080234318-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-25 | — | — | US | disclosed |
| US-20080207634-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-08-28 | — | — | US | disclosed |
| US-20080171740-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | US | disclosed |
| WO-2007087549-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-08-02 | — | — | WO | disclosed |
| EP-1799671-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-06-27 | — | — | EP | disclosed |
| EP-1793825-A2 | CHEMCIAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-06-13 | — | — | EP | disclosed |
| EP-1784185-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2007027999-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007027999-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2006076131-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006036816-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-06 | — | — | WO | disclosed |
| WO-2006028896-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-16 | — | — | WO | disclosed |
| WO-2006026703-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234318-A1 | Chemical Compounds | CCR5, CXCR4, CXCR3 | RAB9A 1478/4885KDM4E 3962/4885NPC1 243/4885 |
| US-20100280010-A1 | CHEMICAL COMPOUNDS | CCR5, CXCR4, CXCR3 | RAB9A 1478/4885KDM4E 3962/4885NPC1 243/4885 |
| US-20080171740-A1 | Chemical Compounds | CXCR4, CCR5, CXCR3 | RAB9A 1507/4885KDM4E 4010/4885NPC1 187/4885 |
| US-20080207634-A1 | Chemical Compounds | CCR5, CXCR4, CXCR3 | RAB9A 1813/4885KDM4E 4363/4885NPC1 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.