Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 10/20 | 0.62 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.62 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.62 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | F13A1 | P00488 | 1/20 | 0.55 |
| ▸ | PGK1 | P00558 | 2/20 | 0.54 |
| ▸ | PGK2 | P07205 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ESRRG | P62508 | 1/20 | 0.50 |
| ▸ | PTPRC | P08575 | 2/20 | 0.49 |
| ▸ | PTPRB | P23467 | 2/20 | 0.49 |
| ▸ | CDC25A | P30304 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5532064 | 0.84 | PTPN1 (0.45) | PTPN1PTPN2PTPN6PTPN11KDM4E | |
| SCHEMBL1008256 | 0.83 | KDM4E (0.64) | KDM4EF13A1SMN1; SMN2ESRRGALDH1A1 | |
| SCHEMBL3741701 | 0.79 | PTPN1 (0.60) | PTPN1PTPN2KDM4EF13A1SMN1; SMN2 | |
| SCHEMBL10592850 | 0.79 | KDM4E (0.84) | KDM4EF13A1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL12184914 | 0.78 | ESRRG (0.67) | KDM4EF13A1SMN1; SMN2ESRRGALDH1A1 | |
| SCHEMBL4316970 | 0.77 | PTPN1 (1.00) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL20672233 | 0.77 | PTPN1 (0.78) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL13372416 | 0.77 | PTPN1 (0.62) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL27458185 | 0.75 | KDM4E (0.62) | KDM4EF13A1SMN1; SMN2ESRRGALDH1A1 | |
| SCHEMBL330067 | 0.75 | PTPN1 (0.70) | PTPN1PTPN2PTPN6PTPN11PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094677-A | Protein tyrosine phosphatase inhibitors and methods of use thereof | CEPTYR INC (US) | 2007-12-26 | — | — | CN | claimed |
| US-20060142250-A1 | Protein tyrosine phosphatase inhibitors and methods of use thereof | FALCON TECHNOLOGY PARTNERS L.P. | 2006-06-29 | — | — | US | claimed |
| US-7829737-B2 | Protein tyrosine phosphatase inhibitors and methods of use thereof | CEPTYR, INC. (US) | 2010-11-09 | — | — | US | disclosed |
| US-20090131374-A1 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | CEPTYR, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| US-7504389-B2 | Protein tyrosine phosphatase inhibitors and methods of use thereof | CEPTYR, INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-20080161592-A1 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | CEPTYR, INC. (US) | 2008-07-03 | — | — | US | disclosed |
| US-20060142250-A1 | Protein tyrosine phosphatase inhibitors and methods of use thereof | FALCON TECHNOLOGY PARTNERS L.P. | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161592-A1 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | PPM1B, PTPN1, PTPN5 | PTPN1 2/4885PTPN2 5/4885PTPN6 10/4885 |
| US-20060142250-A1 | Protein tyrosine phosphatase inhibitors and methods of use thereof | PPM1B, PTPN1, PTPN5 | PTPN1 2/4885PTPN2 5/4885PTPN6 10/4885 |
| US-20090131374-A1 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | PPM1B, PTPN1, PTPN5 | PTPN1 2/4885PTPN2 5/4885PTPN6 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.