Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.52 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5007251 | 0.87 | PTGER1 (0.47) | PTGDR2PTGER1CYP2C9ATMMEN1 | |
| SCHEMBL5102945 | 0.85 | PTGER1 (0.73) | CHRM1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL5099728 | 0.79 | PTGER1 (0.65) | PTGER1PTGER4PTGER3PTGER2TBXA2R | |
| SCHEMBL21900449 | 0.79 | CHRM1 (0.51) | CHRM1PTGDR2AGPAT2TP53MEN1 | |
| SCHEMBL1628791 | 0.75 | L3MBTL1 (0.62) | CHRM1ATMMAPTALOX15TSHR | |
| Hydrochloric Acid SCHEMBL2525349 | 0.74 | L3MBTL1 (0.61) | CHRM1ATMMAPTALOX15TSHR | |
| SCHEMBL3731427 | 0.73 | PTGER1 (0.51) | PTGDR2PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL9285164 | 0.73 | ALDH1A1 (0.49) | MEN1GAATSHRKMT2A | |
| SCHEMBL7827157 | 0.72 | AKR1B1 (0.67) | PTGER1PTGER4PTGER3PTGER2GAA | |
| SCHEMBL1412638 | 0.72 | L3MBTL1 (0.50) | MEN1GAAMAPTTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255173-A1 | Novel Specific Caspase-10 Inhibitors | MERCK PATENT GESELLSCHAFT (DE) | 2008-10-16 | — | — | US | claimed |
| US-7829721-B2 | Specific caspase-10 inhibitors | MERCK PATENT GMBH (DE) | 2010-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255173-A1 | Novel Specific Caspase-10 Inhibitors | CASP10, CASP1, CASP5 | CHRM1 4883/4885PTGDR2 3995/4885PTGER1 1110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.