SCHEMBL373843

SCHEMBL373843

C=C(C)C(=O)OCCOc1cc(-n2nc3ccc(C)cc3n2)c(O)c(C(C)(C)C)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.35
RAB9A P51151 5/20 0.35
ALDH1A1 P00352 4/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
KDM4E B2RXH2 5/20 0.35
MAPT P10636 4/20 0.35
TDP1 Q9NUW8 3/20 0.35
HPGD P15428 3/20 0.35
POLB P06746 3/20 0.34
APEX1 P27695 1/20 0.33
HTT P42858 1/20 0.33
NPSR1 Q6W5P4 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
LMNA P02545 1/20 0.32
RXFP1 Q9HBX9 1/20 0.32
IGF2BP2 Q9Y6M1 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
CA1 P00915 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29613654 1.00 NPC1 (0.35) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL8397404 0.95 TDP1 (0.37) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL2238210 0.91 POLB (0.33) TDP1POLBAPEX1HTT
SCHEMBL29399534 0.90 POLB (0.35) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL2778858 0.90 POLB (0.35) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL13021486 0.89 POLB (0.32) TDP1POLBAPEX1HTT
SCHEMBL30965309 0.88 HTT (0.35) RAB9ASMN1; SMN2KDM4EMAPTTDP1
SCHEMBL21956086 0.88 HTT (0.35) RAB9ASMN1; SMN2KDM4EMAPTTDP1
SCHEMBL7177419 0.87 THRB (0.39) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E
SCHEMBL14213069 0.86 NPC1 (0.34) NPC1RAB9AALDH1A1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0488145-B1 Ultraviolet light absorbing intraocular lens MENICON CO LTD (JP) 1999-06-09 EP claimed
US-5147902-A Benzotriazole compound MENICON CO., LTD. (JP) 1992-09-15 US claimed
EP-0488145-A2 Ultraviolet light absorbing ocular lens Menicon Co., Ltd. (JP) 1992-06-03 EP claimed
JP-4193869-A None JP disclosed
US-20250115701-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2025-04-10 US disclosed
US-12209154-B2 Polymer material MENICON CO., LTD. (JP) 2025-01-28 US disclosed
WO-2023068316-A1 MATERIAL FOR SOFT CONTACT LENS HAVING CONTRAST IMPROVEMENT FUNCTION 興和株式会社 2023-04-27 WO disclosed
US-20220244428-A1 OPHTHALMIC MEDICAL INSTRUMENT INCLUDING PHOTOCHROMIC POLYMER AND PRODUCTION METHOD FOR OPHTHALMIC MEDICAL INSTRUMENT MENICON CO., LTD. (JP) 2022-08-04 US disclosed
EP-3992695-A1 OPHTHALMIC MEDICAL INSTRUMENT INCLUDING PHOTOCHROMIC POLYMER AND PRODUCTION METHOD FOR OPHTHALMIC MEDICAL INSTRUMENT Menicon Co., Ltd. (JP) 2022-05-04 EP disclosed
CN-114096911-A Ophthalmic medical devices comprising photochromic polymers and methods of making the same 株式会社目立康 2022-02-25 CN disclosed
US-20210163650-A1 POLYMER MATERIAL MENICON CO., LTD. (JP) 2021-06-03 US disclosed
EP-0872251-A2 Method of sterilizing intraocular lens by electron beam Menicon Co., Ltd. (JP) 1998-10-21 EP disclosed
US-5786434-A A CURABLE COPOLYMER COMPRISING A DIALKYLACRYLAMIDE OR METHACRYLAMIDE, A VINYLLACTAM, A BIS(SILICON-CONTAINING ALKYL)FUMARATE MONOMERS; RADIATION TRANSPARENT, HIGH OXYGEN PERMEABILITY MENICON CO., LTD. (JP) 1998-07-28 US disclosed
US-5741830-A COPOLYMER OF A FLUORINE CONTAINING STYRENE DERIVATIVE AND N,N-DIMETHYL(METH)ACRYLAMIDE MENICON CO., LTD. (JP) 1998-04-21 US disclosed
US-5661194-A POLYMER FROM MONOMERS OF (METH)ACRYLAMIDE TYPE MONOMER, FLUOROALKYL (SILICON-CONTAINING ALKYL) FUMARATE MONOMER, AND CROSSLINKING MONOMER MENICON CO., LTD. (JP) 1997-08-26 US disclosed
EP-0729041-A2 Water-Absorptive soft contact lens Menicon Co., Ltd. (JP) 1996-08-28 EP disclosed
EP-0722110-A2 Water absorptive soft contact lens Menicon Co., Ltd. (JP) 1996-07-17 EP disclosed
US-5147902-A Benzotriazole compound MENICON CO., LTD. (JP) 1992-09-15 US disclosed
JP-H04193869-A PRODUCTION OF NEW BENZOTRIAZOLE COMPOUND SHIPURO KASEI KK 1992-07-13 JP disclosed
EP-0488145-A2 Ultraviolet light absorbing ocular lens Menicon Co., Ltd. (JP) 1992-06-03 EP disclosed