Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.40 |
| ▸ | PAM | P19021 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL8946729 | 0.89 | USP2 (0.50) | EPHX2CES2TSHRUSP2PLA2G4B | |
| Propylene Glycol SCHEMBL3736319 | 0.89 | HSD17B10 (0.48) | EPHX2CES2TSHRUSP2PLA2G4B | |
| Propylene Glycol SCHEMBL443949 | 0.87 | TSHR (0.48) | CES2TSHRUSP2TDP1ALDH1A1 | |
| Alcohol SCHEMBL7530020 | 0.86 | CES2 (0.52) | EPHX2CES2TSHRPLA2G4BPAM | |
| SCHEMBL24207 | 0.86 | — | — | |
| SCHEMBL3729486 | 0.86 | TDP1 (0.46) | EPHX2CES2TSHRUSP2PLA2G4B | |
| Propylene Glycol SCHEMBL282614 | 0.85 | TSHR (0.50) | CES2TSHRUSP2TDP1ALDH1A1 | |
| Ethylene Glycol SCHEMBL3734775 | 0.84 | TSHR (0.54) | EPHX2CES2TSHRPLA2G4BPAM | |
| Hydrochloric Acid SCHEMBL1375034 | 0.84 | CES2 (0.54) | EPHX2CES2TSHRPLA2G4BPAM | |
| SCHEMBL21295324 | 0.84 | CES2 (0.54) | EPHX2CES2TSHRPLA2G4BPAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825178-B2 | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |
| US-20070289481-A1 | Leveling Agent for Floor Polish and Aqueous Floor Polish Composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-12-20 | — | — | US | disclosed |