Fumaric Acid

Fumaric Acid

SCHEMBL3739893

O=C(O)/C=C/C(=O)O.[Mn]

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fumaric Acid SCHEMBL532213 1.00
Maleic Acid SCHEMBL532212 1.00
Maleic Acid SCHEMBL2046430 0.95 TSHR (1.00)
Maleic Acid SCHEMBL20487516 0.95 TSHR (1.00)
Fumaric Acid SCHEMBL3998225 0.95
Fumaric Acid SCHEMBL6875 0.95 TSHR (1.00)
Maleic Acid SCHEMBL613 0.95
Fumaric Acid SCHEMBL615 0.95
Fumaric Acid SCHEMBL2046433 0.95 TSHR (1.00)
Fumaric Acid SCHEMBL623596 0.95 TSHR (1.00)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 106 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3814303-B1 NOVEL CROP NUTRITION AND FORTIFICATION COMPOSITION SML LTD (IN) 2026-04-29 EP claimed
US-20260028294-A1 NOVEL CROP NUTRITION AND FORTIFICATION COMPOSITION SML LIMITED (IN) 2026-01-29 US claimed
US-12454495-B2 Crop nutrition and fortification composition SML Limitied (IN) 2025-10-28 US claimed
CN-115072787-A Preparation method of battery-grade manganese sulfate 贵州金瑞新材料有限责任公司 2022-09-20 CN claimed
CN-107412260-B cGAS-STING pathway activators and uses thereof 北京大学 2022-07-19 CN claimed
EP-3814303-A1 NOVEL CROP NUTRITION AND FORTIFICATION COMPOSITION Sawant, Arun Vitthal (IN) 2021-05-05 EP claimed
WO-2021077566-A1 APPLICATION OF DIVALENT MANGANESE IN PREPARING IMMUNITY ENHANCING DRUG OR ANTITUMOR DRUG 北京大学 2021-04-29 WO claimed
US-20210122681-A1 NOVEL CROP NUTRITION AND FORTIFICATION COMPOSITION SML LIMITED (IN) 2021-04-29 US claimed
CN-112691120-A Application of bivalent manganese in preparation of immune enhancement medicine or anti-tumor medicine 北京大学 2021-04-23 CN claimed
CN-112566885-A Novel crop nutrition and fortification compositions 阿鲁恩·维塔尔·沙旺特 2021-03-26 CN claimed
WO-2019215697-A1 NOVEL CROP NUTRITION AND FORTIFICATION COMPOSITION SAWANT ARUN (IN) 2019-11-14 WO claimed
CN-1718699-A Catalytic combustion adjuvant for coal YIN XIAOLIN (CN) 2006-01-11 CN claimed
US-20040105894-A1 Trace Metals synergized copper nucleotides and copper glycosides for anti-aging and antiviral compositions GUPTA SHYAM K (US) 2004-06-03 US claimed
EP-0924996-B1 USE OF BILAYER FORMING EMULSIFIERS IN NUTRITIONAL COMPOSITIONS COMPRISING DIVALENT METAL SALTS PROCTER & GAMBLE (US) 2002-04-03 EP claimed
JP-3245180-B2 2002-01-07 JP claimed
JP-2000501622-A 2000-02-15 JP claimed
EP-0924996-A1 USE OF BILAYER FORMING EMULSIFIERS IN NUTRITIONAL COMPOSITIONS COMPRISING DIVALENT METAL SALTS THE PROCTER & GAMBLE COMPANY (US) 1999-06-30 EP claimed
US-5888563-A Use of bilayer forming emulsifiers in nutritional compositions comprising divalent mineral salts to minimize off-tastes and interactions with other dietary components THE PROCTER & GAMBLE COMPANY (US) 1999-03-30 US claimed
WO-1998008401-A1 USE OF BILAYER FORMING EMULSIFIERS IN NUTRITIONAL COMPOSITIONS COMPRISING DIVALENT METAL SALTS THE PROCTER & GAMBLE COMPANY (US) 1998-03-05 WO claimed
EP-3814303-B1 NOVEL CROP NUTRITION AND FORTIFICATION COMPOSITION SML LTD (IN) 2026-04-29 EP disclosed
US-20260028294-A1 NOVEL CROP NUTRITION AND FORTIFICATION COMPOSITION SML LIMITED (IN) 2026-01-29 US disclosed
EP-4642749-A1 CROP NUTRITION AND FORTIFICATION COMPOSITION Bhukhanwala, Komal (IN) 2025-11-05 EP disclosed
US-12454495-B2 Crop nutrition and fortification composition SML Limitied (IN) 2025-10-28 US disclosed
CN-119548525-A Application of manganese-containing compound in preparation of medicine for preventing and treating silkworm nuclear polyhedrosis virus 安徽农业大学 2025-03-04 CN disclosed
CN-113613663-B Compositions and methods for increasing T cell function 雀巢产品有限公司 2024-09-03 CN disclosed
WO-2024142112-A1 CROP NUTRITION AND FORTIFICATION COMPOSITION BHUKHANWALA KOMAL (IN) 2024-07-04 WO disclosed
US-11968978-B2 Formulations and methods for treating photosynthetic organisms and enhancing qualities and quantities of yields with glycan composite formulations INNOVATION HAMMER LLC (US) 2024-04-30 US disclosed
US-20230360770-A1 METHOD FOR DETERMINING DIETARY FOOD PATTERNS IN LACTATING WOMEN NESTLE SA (CH) 2023-11-09 US disclosed
US-20230322639-A1 AN ORGANIC AGRICULTURAL COMPOSITION DOSHI HITESHKUMAR ANILKANT (IN) 2023-10-12 US disclosed
EP-4218414-A1 FORMULATIONS AND METHODS FOR TREATING PHOTOSYNTHETIC ORGANISMS AND ENHANCING QUALITIES AND QUANTITIES OF YIELDS WITH GLYCAN COMPOSITE FORMULATIONS Innovation Hammer LLC (US) 2023-08-02 EP disclosed
EP-4211095-A1 AN ORGANIC AGRICULTURAL COMPOSITION Doshi, Hiteshkumar Anilkant (IN) 2023-07-19 EP disclosed
EP-4208043-A1 METHOD FOR DETERMINING DIETARY FOOD PATTERNS IN LACTATING WOMEN Société des Produits Nestlé S.A. (CH) 2023-07-12 EP disclosed
CN-116234785-A Organic agricultural composition 希特逊库玛·阿尼凯特·多希 2023-06-06 CN disclosed
CN-115988970-A Method for determining dietary food patterns of lactating women 雀巢产品有限公司 2023-04-18 CN disclosed
US-20230074223-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MASTITIS NESTLE SA (CH) 2023-03-09 US disclosed
US-20230040010-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MASTITIS NESTLE SA (CH) 2023-02-09 US disclosed
US-20230000931-A1 COMPOSITIONS AND METHODS WITH A PROBIOTIC AND A N-3 FATTY ACID FOR THE PREVENTION OR TREATMENT OF MASTITIS NESTLE SA (CH) 2023-01-05 US disclosed
US-20220409679-A1 COMPOSITIONS AND METHODS WITH A PROBIOTIC AND A NUTRIENT AND/OR MINERAL FOR THE PREVENTION OR TREATMENT OF MASTITIS NESTLE SA (CH) 2022-12-29 US disclosed
US-20220408778-A1 FOOD COMPOSITIONS FOR LACTATING WOMEN NESTLE SA (CH) 2022-12-29 US disclosed
EP-4090172-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MASTITIS Société des Produits Nestlé S.A. (CH) 2022-11-23 EP disclosed
EP-4065147-A1 COMPOSITIONS AND METHODS WITH A PROBIOTIC AND A N-3 FATTY ACID FOR THE PREVENTION OR TREATMENT OF MASTITIS Société des Produits Nestlé S.A. (CH) 2022-10-05 EP disclosed
EP-4064863-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MASTITIS Société des Produits Nestlé S.A. (CH) 2022-10-05 EP disclosed
EP-4065146-A1 COMPOSITIONS AND METHODS WITH A PROBIOTIC AND A NUTRIENT AND/OR MINERAL FOR THE PREVENTION OR TREATMENT OF MASTITIS Société des Produits Nestlé S.A. (CH) 2022-10-05 EP disclosed
CN-115072787-A Preparation method of battery-grade manganese sulfate 贵州金瑞新材料有限责任公司 2022-09-20 CN disclosed
CN-114945380-A Compositions and methods having probiotics and nutrients and/or minerals for preventing or treating mastitis 雀巢产品有限公司 2022-08-26 CN disclosed
CN-114945285-A Compositions and methods for treating mastitis 雀巢产品有限公司 2022-08-26 CN disclosed
CN-107412260-B cGAS-STING pathway activators and uses thereof 北京大学 2022-07-19 CN disclosed
CN-114761029-A Compositions and methods having probiotics and N-3 fatty acids for preventing or treating mastitis 雀巢产品有限公司 2022-07-15 CN disclosed
EP-4025075-A1 FOOD COMPOSITIONS FOR LACTATING WOMEN Société des Produits Nestlé S.A. (CH) 2022-07-13 EP disclosed
CN-114745971-A Compositions and methods for treating mastitis 雀巢产品有限公司 2022-07-12 CN disclosed
US-20220168271-A1 COMPOSITIONS AND METHODS FOR INCREASING T CELL FUNCTION LUDWIG INSTITUTE FOR CANCER RESEARCH LTD (CH) 2022-06-02 US disclosed
CN-114340408-A Food composition for lactating women 雀巢产品有限公司 2022-04-12 CN disclosed
CN-112691120-B Application of bivalent manganese in preparation of immune enhancement medicine or anti-tumor medicine 北京大学 2022-03-29 CN disclosed
WO-2022053946-A1 AN ORGANIC AGRICULTURAL COMPOSITION DOSHI HITESHKUMAR (IN) 2022-03-17 WO disclosed
WO-2022048999-A1 METHOD FOR DETERMINING DIETARY FOOD PATTERNS IN LACTATING WOMEN Société des Produits Nestlé S.A. (CH) 2022-03-10 WO disclosed
EP-3946306-A2 COMPOSITIONS AND METHODS FOR INCREASING T CELL FUNCTION Société des Produits Nestlé S.A. (CH) 2022-02-09 EP disclosed
CN-113930616-A Recovery method of Fumei slag in wet metallurgy 兰州大学 2022-01-14 CN disclosed
CN-113613663-A Compositions and methods for increasing T cell function 雀巢产品有限公司 2021-11-05 CN disclosed
US-20210338720-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MASTITIS SAMUEL TINU MARY (CH) 2021-11-04 US disclosed
US-11122804-B2 Formulations and methods for treating photosynthetic organisms and enhancing qualities and quantities of yields with glycan composite formulations INNOVATION HAMMER LLC (US) 2021-09-21 US disclosed
WO-2021144466-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MASTITIS Société des Produits Nestlé S.A. (CH) 2021-07-22 WO disclosed
EP-3843753-A2 COMPOSITIONS COMPRISING MINERALS, PROTEINS AND FATTY ACIDS FOR THE TREATMENT OF MASTITIS Société des Produits Nestlé S.A. (CH) 2021-07-07 EP disclosed
WO-2021105361-A1 COMPOSITIONS AND METHODS WITH A PROBIOTIC AND A N-3 FATTY ACID FOR THE PREVENTION OR TREATMENT OF MASTITIS Société des Produits Nestlé S.A. (CH) 2021-06-03 WO disclosed
WO-2021105353-A1 COMPOSITIONS AND METHODS WITH A PROBIOTIC AND A NUTRIENT AND/OR MINERAL FOR THE PREVENTION OR TREATMENT OF MASTITIS Société des Produits Nestlé S.A. (CH) 2021-06-03 WO disclosed
WO-2021105345-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MASTITIS Société des Produits Nestlé S.A. (CH) 2021-06-03 WO disclosed
US-11013234-B2 Formulations and methods for treating photosynthetic organisms and enhancing qualities and quantities of yields with glycan composite formulations INNOVATION HAMMER LLC (US) 2021-05-25 US disclosed
EP-3814303-A1 NOVEL CROP NUTRITION AND FORTIFICATION COMPOSITION Sawant, Arun Vitthal (IN) 2021-05-05 EP disclosed
US-20210122681-A1 NOVEL CROP NUTRITION AND FORTIFICATION COMPOSITION SML LIMITED (IN) 2021-04-29 US disclosed
CN-112691120-A Application of bivalent manganese in preparation of immune enhancement medicine or anti-tumor medicine 北京大学 2021-04-23 CN disclosed
CN-112601530-A Composition comprising minerals, proteins and fatty acids for treating mastitis 雀巢产品有限公司 2021-04-02 CN disclosed
CN-112566885-A Novel crop nutrition and fortification compositions 阿鲁恩·维塔尔·沙旺特 2021-03-26 CN disclosed
WO-2021043884-A1 FOOD COMPOSITIONS FOR LACTATING WOMEN Société des Produits Nestlé S.A. (CH) 2021-03-11 WO disclosed
US-20200404913-A1 Formulations And Methods For Treating Photosynthetic Organisms And Enhancing Qualities And Quantities Of Yields With Glycan Composite Formulations INNOVATION HAMMER LLC (US) 2020-12-31 US disclosed
US-20200404912-A1 Formulations And Methods For Treating Photosynthetic Organisms And Enhancing Qualities And Quantities Of Yields With Glycan Composite Formulations INNOVATION HAMMER LLC (US) 2020-12-31 US disclosed
WO-2020201076-A2 COMPOSITIONS AND METHODS FOR INCREASING T CELL FUNCTION Société des Produits Nestlé S.A. (CH) 2020-10-08 WO disclosed
CN-109136571-B Method for extracting valuable metals from lithium ion battery mixed manganese-rich waste leachate 中南大学 2020-04-07 CN disclosed
WO-2020043700-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MASTITIS Société des Produits Nestlé S.A. (CH) 2020-03-05 WO disclosed
US-20200060274-A1 Formulations And Methods For Treating Photosynthetic Organisms And Enhancing Qualities And Quantities Of Yields With Glycan Composite Formulations INNOVATION HAMMER LLC (US) 2020-02-27 US disclosed
WO-2019215697-A1 NOVEL CROP NUTRITION AND FORTIFICATION COMPOSITION SAWANT ARUN (IN) 2019-11-14 WO disclosed
US-20170311598-A1 Formulations And Methods For Treating Photosynthetic Organisms And Enhancing Qualities And Quantities Of Yields With Glycan Composite Formulations INNOVATION HAMMER LLC 2017-11-02 US disclosed
WO-2017189311-A1 FORMULATIONS AND METHODS FOR TREATING PHOTOSYNTHETIC ORGANISMS AND ENHANCING QUALITIES AND QUANTITIES OF YIELDS WITH GLYCAN COMPOSITE FORMULATIONS INNOVATION HAMMER LLC (US) 2017-11-02 WO disclosed
US-20160208107-A1 Compositions for Causing, Enhancing, and/or Expediting Oxo-Biodegradation of Articles and Methods of Production and Use Thereof WANDA M WEDER AND WILLIAM F STRAETER NOT INDIVIDUALLY BUT SOLELY AS TRUSTEES OF THE FAMILY (US) 2016-07-21 US disclosed
US-20150037865-A1 COMPOSITIONS FOR CAUSING, ENHANCING, AND/OR EXPEDITING OXO-BIODEGRADATION OF ARTICLES AND METHODS OF PRODUCTION AND USE THEREOF WANDA WEDER & WILLIAM STRAETER NOT INDIVIDUALLY BUT SOLELY AS TRUSTEES OF THE FAMILY TRUST U T A D (US) 2015-02-05 US disclosed
US-7834210-B2 Hair loss prevention by natural amino acid and peptide complexes BIODERM RESEARCH (US) 2010-11-16 US disclosed
US-20090253668-A1 Hair Loss Prevention by Natural Amino Acid and Peptide Complexes BIODERM RESEARCH (US) 2009-10-08 US disclosed
US-7572933-B2 Skin and hair restoration by natural amino acid peptide complexes BIODERM RESEARCH (US) 2009-08-11 US disclosed
US-20080287536-A1 Skin and Hair Restoration by Natural Amino Acid and Peptide Crown Complexes BIODERM RESEARCH (US) 2008-11-20 US disclosed
US-7427690-B2 Multifunction “crown complexes” from amino acids and peptides for skin and hair restoration BIODERM RESEARCH (US) 2008-09-23 US disclosed
EP-1496759-B1 COMPOSITIONS COMPRISING PROTEIN AND FATTY ACID AND PROCESSES OF THEIR PREPARATION PROCTER & GAMBLE (US) 2008-09-03 EP disclosed
US-7393552-B2 Compositions comprising protein and fatty acid THE PROCTER & GAMBLE COMPANY (US) 2008-07-01 US disclosed
US-20080090297-A1 Methods for determining the metal bioavailability of metal sources NOVUS INTERNATIONAL INC. (US) 2008-04-17 US disclosed
US-20070227399-A1 COMPOSITIONS AND METHODS FOR THE PRESERVATION OF WOOD NOVUS INTERNATIONAL INC. (US) 2007-10-04 US disclosed
US-20070099886-A1 Multifunction \"Crown Complexes\" from Amino Acids and Peptides for Skin and Hair Restoration BIODERM RESEARCH (US) 2007-05-03 US disclosed
CN-1718699-A Catalytic combustion adjuvant for coal YIN XIAOLIN (CN) 2006-01-11 CN disclosed
EP-1496759-A1 COMPOSITIONS COMPRISING PROTEIN AND FATTY ACID AND PROCESSES OF THEIR PREPARATION THE PROCTER & GAMBLE COMPANY (US) 2005-01-19 EP disclosed
WO-2003090560-A1 COMPOSITIONS COMPRISING PROTEIN AND FATTY ACID AND PROCESSES OF THEIR PREPARATION THE PROCTER & GAMBLE COMPANY (US) 2003-11-06 WO disclosed
US-20030203005-A1 Compositions comprising protein and fatty acid and processes of their preparation PROCTER & GAMBLE COMPANY THE 2003-10-30 US disclosed
US-6451341-B1 ADMINISTERING TO ANIMAL DIETARY SUPPLEMENT COMPRISING BUTYLATED HYDROXYTOLUENE(BHT), BUTYLATED HYDROXYANISOLE(BHA), VITAMIN E, AND B-CAROTENE TO PREVENT SKIN CANCER BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2002-09-17 US disclosed
EP-0924996-B1 USE OF BILAYER FORMING EMULSIFIERS IN NUTRITIONAL COMPOSITIONS COMPRISING DIVALENT METAL SALTS PROCTER & GAMBLE (US) 2002-04-03 EP disclosed
EP-0924996-A1 USE OF BILAYER FORMING EMULSIFIERS IN NUTRITIONAL COMPOSITIONS COMPRISING DIVALENT METAL SALTS THE PROCTER & GAMBLE COMPANY (US) 1999-06-30 EP disclosed
US-5888563-A Use of bilayer forming emulsifiers in nutritional compositions comprising divalent mineral salts to minimize off-tastes and interactions with other dietary components THE PROCTER & GAMBLE COMPANY (US) 1999-03-30 US disclosed
WO-1998008401-A1 USE OF BILAYER FORMING EMULSIFIERS IN NUTRITIONAL COMPOSITIONS COMPRISING DIVALENT METAL SALTS THE PROCTER & GAMBLE COMPANY (US) 1998-03-05 WO disclosed
US-5707670-A COATING A SUBSTRATE WITH EMULSIFIER FOR MULTILAYER STRUCTURE, SPREADING A NUTRIENT FERROUS SALT OF DICARBOXYLIC ACID AND MIXING WITH VITAMINS THE PROCTER & GAMBLE COMPANY (US) 1998-01-13 US disclosed
EP-0514451-B1 DIETARY SUPPLEMENTS COMPRISING VITAMINS AND MINERALS LIFESCIENCE CORP (US) 1997-01-15 EP disclosed
EP-0514451-A1 DIETARY SUPPLEMENTS COMPRISING VITAMINS AND MINERALS. UNIV TEXAS (US) 1992-11-25 EP disclosed
WO-1991011117-A2 DIETARY SUPPLEMENTS COMPRISING VITAMINS AND MINERALS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1991-08-08 WO disclosed
WO-1991011117-A2 DIETARY SUPPLEMENTS COMPRISING VITAMINS AND MINERALS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1991-08-08 WO disclosed