Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL532213 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL3739893 | 1.00 | — | — | |
| Maleic Acid SCHEMBL2046430 | 0.95 | TSHR (1.00) | — | |
| Maleic Acid SCHEMBL20487516 | 0.95 | TSHR (1.00) | — | |
| Fumaric Acid SCHEMBL3998225 | 0.95 | — | — | |
| Fumaric Acid SCHEMBL6875 | 0.95 | TSHR (1.00) | — | |
| Maleic Acid SCHEMBL613 | 0.95 | — | — | |
| Fumaric Acid SCHEMBL615 | 0.95 | — | — | |
| Fumaric Acid SCHEMBL2046433 | 0.95 | TSHR (1.00) | — | |
| Fumaric Acid SCHEMBL623596 | 0.95 | TSHR (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107412260-B | cGAS-STING pathway activators and uses thereof | 北京大学 | 2022-07-19 | — | — | CN | claimed |
| WO-2021077566-A1 | APPLICATION OF DIVALENT MANGANESE IN PREPARING IMMUNITY ENHANCING DRUG OR ANTITUMOR DRUG | 北京大学 | 2021-04-29 | — | — | WO | claimed |
| CN-112691120-A | Application of bivalent manganese in preparation of immune enhancement medicine or anti-tumor medicine | 北京大学 | 2021-04-23 | — | — | CN | claimed |
| CN-107412260-A | CGAS-STING Pathway Activation agent and application thereof | 北京大学 | 2017-12-01 | — | — | CN | claimed |
| CN-1718699-A | Catalytic combustion adjuvant for coal | YIN XIAOLIN (CN) | 2006-01-11 | — | — | CN | claimed |
| EP-3448157-B1 | FORMULATIONS AND METHODS FOR TREATING PHOTOSYNTHETIC ORGANISMS AND ENHANCING QUALITIES AND QUANTITIES OF YIELDS WITH GLYCAN COMPOSITE FORMULATIONS | INNOVATION HAMMER LLC (US) | 2025-06-04 | — | — | EP | disclosed |
| US-12317895-B2 | Formulations and methods for treating photosynthetic organisms and enhancing qualities and quantities of yields with glycan composite formulations | INNOVATION HAMMER LLC (US) | 2025-06-03 | — | — | US | disclosed |
| CN-119548525-A | Application of manganese-containing compound in preparation of medicine for preventing and treating silkworm nuclear polyhedrosis virus | 安徽农业大学 | 2025-03-04 | — | — | CN | disclosed |
| US-20240246896-A1 | METHOD FOR PRODUCING EASILY POLYMERIZABLE COMPOUND | NIPPON SHOKUBAI CO., LTD. (JP) | 2024-07-25 | — | — | US | disclosed |
| US-11968978-B2 | Formulations and methods for treating photosynthetic organisms and enhancing qualities and quantities of yields with glycan composite formulations | INNOVATION HAMMER LLC (US) | 2024-04-30 | — | — | US | disclosed |
| EP-4353708-A1 | METHOD FOR PRODUCING EASILY POLYMERIZABLE COMPOUND | Nippon Shokubai Co., Ltd. (JP) | 2024-04-17 | — | — | EP | disclosed |
| CN-117412945-A | Process for producing easily polymerizable compound | 株式会社日本触媒 | 2024-01-16 | — | — | CN | disclosed |
| US-20020049291-A1 | Anionic vinyl/dicarboxylic acid polymers and uses thereof | SPECIALTY FERTILIZER PRODUCTS, LLC | 2002-04-25 | — | — | US | disclosed |
| WO-2001082869-A2 | ANIONIC VINYL/DICARBOXYLIC ACID POLYMERS AND USES THEREOF | SANDERS JOHN LARRY (US) | 2001-11-08 | — | — | WO | disclosed |
| CN-1065637-C | A device for transferring a toner image from an image-forming medium to a receiving material | OCE NETHERLAND B V (NL) | 2001-05-09 | — | — | CN | disclosed |
| CN-1115428-A | A device for transferring a toner image from an image-forming medium to a receiving material | OCE NEDERLAND BV (NL) | 1996-01-24 | — | — | CN | disclosed |
| EP-0299942-B1 | ANTIFREEZE COMPOSITION | NIPPON SHOKUBAI CO., LTD. (JP) | 1992-12-02 | — | — | EP | disclosed |
| US-5080818-A | Antifreeze composition | NIPPON SHOKUBAI KAGAKU KOGYO CO., LTD. (JP) | 1992-01-14 | — | — | US | disclosed |
| EP-0299942-A2 | Antifreeze composition | NIPPON SHOKUBAI CO., LTD. (JP) | 1989-01-18 | — | — | EP | disclosed |
| US-4061542-A | 2-Methyl-L-arginine produced by cultivating streptomyces strain | HOFFMANN-LA ROCHE INC. (US) | 1977-12-06 | — | — | US | disclosed |