SCHEMBL373997

SCHEMBL373997

C=C(C)C(=O)Oc1cccc(C(C)(C)c2cccc(OC(=O)C(=C)C)c2)c1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ELANE P08246 1/20 0.46
CYP3A4 P08684 1/20 0.45
LMNA P02545 1/20 0.41
KMT2A Q03164 4/20 0.40
ATM Q13315 2/20 0.40
ESR1 P03372 2/20 0.40
ESR2 Q92731 2/20 0.40
ACHE P22303 2/20 0.38
MEN1 O00255 2/20 0.38
PRSS1 P07477 1/20 0.35
ACR P10323 1/20 0.35
ALDH1A1 P00352 1/20 0.34
TRPV1 Q8NER1 1/20 0.34
TRPA1 O75762 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29584051 1.00 ELANE (0.46) ELANECYP3A4LMNAKMT2AATM
SCHEMBL28992157 0.90 ELANE (0.46) ELANECYP3A4LMNAKMT2AATM
SCHEMBL14173078 0.88 ELANE (0.51) ELANECYP3A4LMNAKMT2AATM
SCHEMBL26059944 0.86 ELANE (0.43) ELANECYP3A4LMNAKMT2AATM
SCHEMBL15836532 0.86 ATM (0.48) ELANELMNAATMPRSS1ACR
SCHEMBL218655 0.84 ELANE (0.56) ELANECYP3A4LMNAKMT2AATM
SCHEMBL29584042 0.83 ELANE (0.43) ELANECYP3A4LMNAKMT2AATM
SCHEMBL373175 0.83 ELANE (0.43) ELANECYP3A4LMNAKMT2AATM
SCHEMBL15836493 0.82 ELANE (0.42) ELANECYP3A4LMNAKMT2AATM
SCHEMBL18841616 0.82 ELANE (0.40) ELANECYP3A4LMNAKMT2AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6346594-B1 SILICONE POLYMER FOR INTRAOCULAR LENSES WITH AMINE GROUPS MENICON CO., LTD. (JP) 2002-02-12 US claimed
EP-0600269-B1 Soft ocular lens material MENICON CO LTD (JP) 1998-02-04 EP claimed
US-5416180-A Fluorine containing (meth)acrylate polymers MENICON CO., LTD. (JP) 1995-05-16 US claimed
EP-0600269-A2 Soft ocular lens material Menicon Co., Ltd. (JP) 1994-06-08 EP claimed
EP-3995493-B1 CHROMENE COMPOUND AND PHOTOCHROMIC OPTICAL ARTICLE TOKUYAMA CORP (JP) 2024-07-03 EP disclosed
EP-2657304-B1 AZO DYE, OCULAR LENS MATERIAL, METHOD FOR PRODUCING OCULAR LENS MATERIAL, AND OCULAR LENS MENICON CO LTD (JP) 2022-12-07 EP disclosed
US-20220213050-A1 CHROMENE COMPOUND AND PHOTOCHROMIC OPTICAL ARTICLE TOKUYAMA CORPORATION (JP) 2022-07-07 US disclosed
EP-3995493-A1 CHROMENE COMPOUND AND PHOTOCHROMIC OPTICAL ARTICLE Tokuyama Corporation (JP) 2022-05-11 EP disclosed
EP-3121643-B1 OPHTHALMIC LENS MENICON CO LTD (JP) 2020-07-22 EP disclosed
US-20180356561-A1 GEL, GEL MANUFACTURING METHOD, LENS, CONTACT LENS SURFACE MODIFIER, POLYMERIZABLE COMPOSITION, AND POLYMER JSR CORPORATION (JP) 2018-12-13 US disclosed
EP-3121643-A1 OPHTHALMIC LENS Menicon Co., Ltd. (JP) 2017-01-25 EP disclosed
EP-2453292-B1 SOFT HYBRID CONTACT LENS, METHOD FOR PRODUCING SAME, AND HYDRATION METHOD MENICON CO LTD (JP) 2016-09-07 EP disclosed
EP-0584826-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-03-02 EP disclosed
EP-0578087-A2 Ocular lens material Menicon Co., Ltd. (JP) 1994-01-12 EP disclosed
US-5041511-A Vinyl benzene acrylate or methacrylate crosslinking agent MENICON CO., LTD. (JP) 1991-08-20 US disclosed
US-4954586-A COPOLYMER OF A FLUORINE CONTAINING (METH)ACRYLATE, AN ALKYL (METH)ACRYLATE, A POLYSILOXANE AND A URETHANE CONTAINING POLYSILOXANE MENICON CO., LTD (JP) 1990-09-04 US disclosed
EP-0132032-B1 IMPROVED PROCESSABLE RADIATION CURABLE POLY(VINYL CHLORIDE) RESIN COMPOSITIONS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-03-15 EP disclosed
US-4631229-A CONTAINING CARBONYL- OR THIOCARBONYLAMINO GROUPS; NONEXUDING OIL MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1986-12-23 US disclosed
US-4559382-A WITH AN ETHYLENICALLY UNSATURATED COMPOUND HAVING CARBONYLAMINO ORTHIOCARBONYLAMINO GROUPS; DIMENSIONAL STABILITY MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1985-12-17 US disclosed
EP-0132032-A2 Improved processable radiation curable poly(vinyl chloride) resin compositions MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1985-01-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220213050-A1 CHROMENE COMPOUND AND PHOTOCHROMIC OPTICAL ARTICLE CRY1, CRY2, TRIP13 ELANE 2505/4885CYP3A4 635/4885LMNA 316/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.