Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27804148 | 0.88 | TDP1 (0.47) | TDP1SIRT3PTGDR2L3MBTL1KDM6B | |
| SCHEMBL4998464 | 0.84 | KDM6B (0.51) | PTGDR2KDM6BKDM4CGABRPGABRD | |
| SCHEMBL4998341 | 0.84 | KDM6B (0.51) | PTGDR2KDM6BKDM4CGABRPGABRD | |
| SCHEMBL5002411 | 0.84 | KDM6B (0.51) | PTGDR2KDM6BKDM4CGABRPGABRD | |
| SCHEMBL5002870 | 0.84 | KDM6B (0.51) | PTGDR2KDM6BKDM4CGABRPGABRD | |
| SCHEMBL6072747 | 0.84 | KDM6B (0.51) | PTGDR2KDM6BKDM4CGABRPGABRD | |
| SCHEMBL9002466 | 0.83 | SIRT3 (0.61) | TDP1SIRT3L3MBTL1KDM6BKDM4C | |
| SCHEMBL9879956 | 0.83 | PTGDR2 (0.45) | TDP1PTGDR2L3MBTL1KDM6BKDM4C | |
| SCHEMBL3634352 | 0.83 | TDP1 (0.49) | TDP1SIRT3L3MBTL1KDM6BKDM4C | |
| SCHEMBL4005290 | 0.81 | GABRP (0.55) | TDP1PTGDR2L3MBTL1KDM6BKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 117 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4377445-A1 | EXPANSION OF RETINAL PIGMENT EPITHELIUM CELLS | Lineage Cell Therapeutics, Inc. (US) | 2024-06-05 | — | — | EP | disclosed |
| US-11987810-B2 | RPE cell populations and methods of generating same | CELL CURE NEUROSCIENCES LTD. (IL) | 2024-05-21 | — | — | US | disclosed |
| CN-118021843-A | Method for measuring efficacy of retinal disease therapy | 谱系细胞疗法公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-117957311-A | Expansion of retinal pigment epithelial cells | 谱系细胞疗法公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-113038951-B | Method for treating amyotrophic lateral sclerosis | 耶达研究及发展有限公司 | 2024-04-30 | — | — | CN | disclosed |
| EP-4351334-A1 | METHODS AND COMPOSITIONS FOR TREATING RETINAL DISEASES AND CONDITIONS | Lineage Cell Therapeutics, Inc. (US) | 2024-04-17 | — | — | EP | disclosed |
| US-11891622-B2 | RPE cell populations and methods of generating same | CELL CURE NEUROSCIENCES LTD. (IL) | 2024-02-06 | — | — | US | disclosed |
| CN-117479835-A | Methods and compositions for treating retinal diseases and conditions | 谱系细胞疗法公司 | 2024-01-30 | — | — | CN | disclosed |
| WO-2023211857-A1 | METHODS AND COMPOSITIONS FOR TREATING VISION LOSS | Lineage Cell Therapeutics, Inc. (US) | 2023-11-02 | — | — | WO | disclosed |
| US-11746324-B2 | Large scale production of retinal pigment epithelial cells | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2023-09-05 | — | — | US | disclosed |
| US-20110177594-A1 | STEM CELLS CULTURE SYSTEMS | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED (US) | 2011-07-21 | — | — | US | disclosed |
| US-20110027333-A1 | STEM CELL-DERIVED RETIN RETINAL PIGMENT EPITHELIAL CELLS | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2011-02-03 | — | — | US | disclosed |
| CN-101688178-A | Stem cell-derived retinal pigment epithelial cells | HADASIT MED RES SERVICE | 2010-03-31 | — | — | CN | disclosed |
| EP-2147094-A1 | STEM CELL-DERIVED RETINAL PIGMENT EPITHELIAL CELLS | Hadasit Medical Research Services&Development Limited (IL) | 2010-01-27 | — | — | EP | disclosed |
| US-20090104695-A1 | Stem Cells Culture Systems | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED (IL) | 2009-04-23 | — | — | US | disclosed |
| WO-2008129554-A1 | STEM CELL-DERIVED RETINAL PIGMENT EPITHELIAL CELLS | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED (IL) | 2008-10-30 | — | — | WO | disclosed |
| EP-1844136-A2 | STEM CELLS CULTURE SYSTEMS | HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) | 2007-10-17 | — | — | EP | disclosed |
| CN-1835922-A | Process for preparing 4-aryl-nicotinamide derivatives | HOFFMANN LA ROCHE (CH) | 2006-09-20 | — | — | CN | disclosed |
| CN-1835922-A | Process for preparing 4-aryl-nicotinamide derivatives | HOFFMANN LA ROCHE (CH) | 2006-09-20 | — | — | CN | disclosed |
| WO-2006070370-A2 | STEM CELLS CULTURE SYSTEMS | HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED (IL) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11746324-B2 | Large scale production of retinal pigment epithelial cells | ALDH1A2, ALDH1A3, POU2F1 | TDP1 3939/4885SIRT3 1452/4885PTGDR2 1325/4885 |
| US-11987810-B2 | RPE cell populations and methods of generating same | ALDH1A2, ALDH1A3, CRABP2 | TDP1 3563/4885SIRT3 3154/4885PTGDR2 3562/4885 |
| US-20110027333-A1 | STEM CELL-DERIVED RETIN RETINAL PIGMENT EPITHELIAL CELLS | ALDH1A2, NR2E3, RB1 | TDP1 4117/4885SIRT3 80/4885PTGDR2 3591/4885 |
| US-11891622-B2 | RPE cell populations and methods of generating same | ALDH1A2, ALDH1A3, CRABP2 | TDP1 3563/4885SIRT3 3154/4885PTGDR2 3562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.