Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 7/20 | 0.62 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.62 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LTA4H | P09960 | 4/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.52 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3091164 | 0.89 | FFAR1 (0.68) | FFAR1FFAR4NR1H4ALDH1A1LMNA | |
| SCHEMBL11156485 | 0.88 | FFAR1 (0.67) | FFAR1FFAR4LTA4HEPHX2LTB4R | |
| SCHEMBL717900 | 0.88 | TDP1 (0.56) | ALDH1A1L3MBTL1ALOX5TDP1 | |
| SCHEMBL2773462 | 0.85 | FFAR1 (0.68) | FFAR1FFAR4NR1H4ALDH1A1LMNA | |
| SCHEMBL6175000 | 0.85 | TDP1 (0.53) | ALDH1A1L3MBTL1ALOX5TDP1 | |
| SCHEMBL19825762 | 0.84 | FFAR1 (0.61) | FFAR1FFAR4NR1H4ALDH1A1LMNA | |
| SCHEMBL2959389 | 0.84 | FFAR1 (0.68) | FFAR1FFAR4LTA4HEPHX2LTB4R | |
| SCHEMBL2871406 | 0.84 | FFAR1 (0.77) | FFAR1FFAR4LTA4HEPHX2POLB | |
| SCHEMBL8010686 | 0.84 | FFAR1 (0.72) | FFAR1FFAR4ALDH1A1L3MBTL1LTA4H | |
| SCHEMBL7159712 | 0.83 | CYP4F2 (0.64) | L3MBTL1ALOX5GAAKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101868463-B | Novel polyspirocyclic compounds, their use in the treatment of malaria or toxoplasmosis and processes for their preparation | UNIV JOSEPH FOURIER | 2013-05-01 | — | — | CN | disclosed |
| US-8389569-B2 | Polyspirane compounds, application thereof in the treatment of malaria or toxoplasmosis and method for preparing same | UNIVERSITE JOSEPH FOURIER (FR) | 2013-03-05 | — | — | US | disclosed |
| US-8389569-B2 | Polyspirane compounds, application thereof in the treatment of malaria or toxoplasmosis and method for preparing same | UNIVERSITE JOSEPH FOURIER (FR) | 2013-03-05 | — | — | US | disclosed |
| US-8389569-B2 | Polyspirane compounds, application thereof in the treatment of malaria or toxoplasmosis and method for preparing same | UNIVERSITE JOSEPH FOURIER (FR) | 2013-03-05 | — | — | US | disclosed |
| EP-2195323-B1 | Polyspirane compounds, use thereof in the treatment of malaria or toxoplasmosis and method for their preparation | UNIV JOSEPH FOURIER (FR) | 2011-12-28 | — | — | EP | disclosed |
| US-20100298422-A1 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2010-11-25 | — | — | US | disclosed |
| US-20100298422-A1 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2010-11-25 | — | — | US | disclosed |
| US-20100298422-A1 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2010-11-25 | — | — | US | disclosed |
| CN-101868463-A | Novel polyspirocyclic compounds, their use in the treatment of malaria or toxoplasmosis and processes for their preparation | UNIV JOSEPH FOURIER | 2010-10-20 | — | — | CN | disclosed |
| WO-2009077677-A2 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | UNIVERSITE JOSEPH FOURIER (FR) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298422-A1 | NOVEL POLYSPIRANE COMPOUNDS, APPLICATION THEREOF IN THE TREATMENT OF MALARIA OR TOXOPLASMOSIS AND METHOD FOR PREPARING SAME | FLOT1, PHOSPHO1, GPAA1 | FFAR1 3390/4885FFAR4 4056/4885NR1H4 619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.