Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 9/20 | 0.68 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.61 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.60 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 2/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3091164 | 0.96 | FFAR1 (0.68) | FFAR1FFAR4CYP4F2CYP4A11NR1H4 | |
| SCHEMBL21171688 | 0.88 | CYP4F2 (0.60) | FFAR1FFAR4CYP4F2CYP4A11NR1H4 | |
| SCHEMBL19825762 | 0.87 | FFAR1 (0.61) | FFAR1FFAR4NR1H4LMNAL3MBTL1 | |
| SCHEMBL10733098 | 0.87 | FFAR1 (0.60) | FFAR1FFAR4CYP4F2CYP4A11NR1H4 | |
| SCHEMBL21171917 | 0.87 | CYP4F2 (0.63) | FFAR1FFAR4CYP4F2CYP4A11NR1H4 | |
| SCHEMBL19266379 | 0.87 | CYP4F2 (0.77) | FFAR1FFAR4CYP4F2CYP4A11NR1H4 | |
| SCHEMBL8890454 | 0.86 | FFAR1 (0.59) | FFAR1FFAR4NR1H4LMNAL3MBTL1 | |
| SCHEMBL3744601 | 0.85 | FFAR1 (0.62) | FFAR1FFAR4NR1H4TDP1LMNA | |
| SCHEMBL8888760 | 0.85 | FFAR1 (0.58) | FFAR1FFAR4NR1H4LMNAL3MBTL1 | |
| SCHEMBL8550447 | 0.85 | ABCB1 (0.57) | FFAR1FFAR4CYP4F2CYP4A11TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140045800-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-02-13 | — | — | US | disclosed |
| US-8372823-B2 | Tetracyclic inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-02-12 | — | — | US | disclosed |
| EP-2152082-B1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | SCRIPPS RESEARCH INST (US) | 2012-08-29 | — | — | EP | disclosed |
| US-20100249078-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPS RESEARCH INSTITUTE (US) | 2010-09-30 | — | — | US | disclosed |
| EP-2152082-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | The Scripps Research Institute (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008147553-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249078-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, APEH | FFAR1 16/4885FFAR4 11/4885CYP4F2 1053/4885 |
| US-20140045800-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, APEH | FFAR1 16/4885FFAR4 11/4885CYP4F2 1053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.