Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13672772 | 0.88 | MAOB (0.46) | DRD2DRD4DRD3CYP4F2CYP4A11 | |
| SCHEMBL18740033 | 0.85 | ALDH1A1 (0.53) | KCNH2DRD2DRD4DRD3CYP4F2 | |
| SCHEMBL2368219 | 0.85 | MAOB (0.43) | KCNH2CYP4F2CYP4A11MAOBBCHE | |
| SCHEMBL7254138 | 0.85 | PRSS1 (0.47) | MAOBKDM4EALDH1A1 | |
| SCHEMBL3110653 | 0.83 | KCNH2 (0.54) | KCNH2DRD2DRD4DRD3HTR1A | |
| SCHEMBL2063087 | 0.83 | KCNA3 (0.50) | DRD2DRD4DRD3CYP4F2CYP4A11 | |
| SCHEMBL5961821 | 0.82 | KCNH2 (0.50) | KCNH2DRD2DRD4DRD3ALDH1A1 | |
| SCHEMBL3738140 | 0.81 | KCNH2 (0.52) | KCNH2DRD2DRD4DRD3HTR1A | |
| SCHEMBL2932600 | 0.81 | KMT2A (0.51) | DRD2HTR1AHTR2BBCHEKDM4E | |
| SCHEMBL12970221 | 0.81 | KDM4E (0.58) | KCNH2DRD2DRD4DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913733-B2 | Substituted piperidines thiazolyl acetamides as glycosidase inhibitors and uses thereof | ALECTOS THERAPEUTICS INC. (CA) | 2021-02-09 | — | — | US | disclosed |
| EP-3389658-B1 | GLYCOSIDASE INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2020-11-25 | — | — | EP | disclosed |
| US-20180362517-A1 | GLYCOSIDASE INHIBITORS AND USES THEREOF | ALECTOS THERAPEUTICS, INC. (CA) | 2018-12-20 | — | — | US | disclosed |
| EP-3389658-A1 | GLYCOSIDASE INHIBITORS AND USES THEREOF | Merck Sharp & Dohme Corp. (US) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017106254-A1 | GLYCOSIDASE INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2017-06-22 | — | — | WO | disclosed |
| US-8354092-B2 | Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354092-B2 | Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354092-B2 | Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| EP-2468734-A1 | Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry | Siemens Medical Solutions USA, Inc. (US) | 2012-06-27 | — | — | EP | disclosed |
| US-20100317842-A1 | Development of Molecular Imaging Probes for Carbonic Anhydrase-IX Using Click Chemistry | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-12-16 | — | — | US | disclosed |
| EP-2129666-A2 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | Siemens Medical Solutions USA, Inc. (US) | 2009-12-09 | — | — | EP | disclosed |
| US-20090123372-A1 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | SIEMENS MEDICAL SOLUTIONS USA, INC. | 2009-05-14 | — | — | US | disclosed |
| US-20090123372-A1 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | SIEMENS MEDICAL SOLUTIONS USA, INC. | 2009-05-14 | — | — | US | disclosed |
| US-20090123372-A1 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | SIEMENS MEDICAL SOLUTIONS USA, INC. | 2009-05-14 | — | — | US | disclosed |
| US-20090105292-A9 | Glucocorticoid Receptor Modulator Compounds and Methods | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2009-04-23 | — | — | US | disclosed |
| WO-2008124703-A2 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2008-10-16 | — | — | WO | disclosed |
| US-20070281959-A1 | Glucocorticoid receptor modulator compounds and methods | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2007-12-06 | — | — | US | disclosed |
| US-20070254917-A1 | INTRACELLULAR RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS INC. | 2007-11-01 | — | — | US | disclosed |
| EP-1778233-A1 | INTRACELLULAR RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS, INC. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006019716-A1 | INTRACELLULAR RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS, INC. (US) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317842-A1 | Development of Molecular Imaging Probes for Carbonic Anhydrase-IX Using Click Chemistry | CA9, CA4, CA13 | KCNH2 2971/4885DRD2 4834/4885DRD4 4848/4885 |
| US-10913733-B2 | Substituted piperidines thiazolyl acetamides as glycosidase inhibitors and uses thereof | OGA, ENGASE, GAA | KCNH2 2054/4885DRD2 2869/4885DRD4 3097/4885 |
| US-20070254917-A1 | INTRACELLULAR RECEPTOR MODULATOR COMPOUNDS AND METHODS | CASR, GRK2, RYR2 | KCNH2 1276/4885DRD2 1654/4885DRD4 3078/4885 |
| US-20090123372-A1 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY | CA9, CA4, CA13 | KCNH2 2971/4885DRD2 4834/4885DRD4 4848/4885 |
| US-20180362517-A1 | GLYCOSIDASE INHIBITORS AND USES THEREOF | ENGASE, OGA, GAA | KCNH2 3633/4885DRD2 2751/4885DRD4 2973/4885 |
| US-20090105292-A9 | Glucocorticoid Receptor Modulator Compounds and Methods | NR3C1, NR3C2, MC2R | KCNH2 4306/4885DRD2 2477/4885DRD4 2903/4885 |
| US-20070281959-A1 | Glucocorticoid receptor modulator compounds and methods | NR3C1, NR3C2, MC2R | KCNH2 4306/4885DRD2 2477/4885DRD4 2903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.