SCHEMBL3746865

SCHEMBL3746865

C=CC(=O)OCCSc1c(C=O)ccc2ccccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 2/20 0.41
GAA P10253 2/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
TSHR P16473 5/20 0.34
HPGD P15428 2/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
ALDH1A1 P00352 4/20 0.33
TP53 P04637 2/20 0.33
HIF1A Q16665 2/20 0.33
CYP3A4 P08684 1/20 0.33
HSD17B10 Q99714 1/20 0.33
ERN1 O75460 2/20 0.33
PTGDR2 Q9Y5Y4 1/20 0.31
LMNA P02545 1/20 0.31
USP2 O75604 1/20 0.31
PAK1 Q13153 1/20 0.31
KDM4E B2RXH2 2/20 0.31
POLB P06746 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13134318 0.80 THRB (0.48) THRBGAATDP1L3MBTL1TSHR
SCHEMBL3746869 0.79 THRB (0.47) THRBTDP1TSHRHPGDMEN1
SCHEMBL1491949 0.75 THRB (0.51) THRBGAATDP1TSHRHPGD
SCHEMBL7712533 0.74 THRB (0.56) THRBTSHRHPGDKMT2AALDH1A1
SCHEMBL42562 0.72 THRB (0.58) THRBTDP1TSHRHPGDMEN1
SCHEMBL8028277 0.72 THRB (0.44) THRBTSHRHPGDMEN1KMT2A
SCHEMBL8044874 0.71 TSHR (0.46) THRBTSHRHPGDMEN1KMT2A
SCHEMBL29311777 0.70 ALDH1A1 (0.50) THRBTSHRHPGDMEN1KMT2A
Acrylic Acid Ethyl Ester SCHEMBL2649669 0.70 ALDH1A1 (0.46) THRBHPGDKMT2AALDH1A1TP53
SCHEMBL4557878 0.70 THRB (0.44) THRBTDP1TSHRHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7833621-B2 Light management films with zirconia particles 3M INNOVATIVE PROPERTIES COMPANY (US) 2010-11-16 US disclosed
US-20090047486-A1 LIGHT MANAGEMENT FILMS WITH ZIRCONIA PARTICLES 3M INNOVATIVE PROPERTIES COMPANY 2009-02-19 US disclosed
EP-1869509-A2 LIGHT MANAGEMENT FILMS WITH ZIRCONIA PARTICLES 3M Innovative Properties Company (US) 2007-12-26 EP disclosed
WO-2006098899-A2 LIGHT MANAGEMENT FILMS WITH ZIRCONIA PARTICLES 3M INNOVATIVE PROPERTIES COMPANY (US) 2006-09-21 WO disclosed
US-20060204745-A1 Light management films with zirconia particles 3M INNOVATIVE PROPERTIES COMPANY 2006-09-14 US disclosed