Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | KMT5B | Q4FZB7 | 2/20 | 0.32 |
| ▸ | KMT5C | Q86Y97 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | TDO2 | P48775 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3011458 | 0.85 | CHEK1 (0.41) | CHEK1KCNH2CNR1RIPK1ADORA2A | |
| SCHEMBL3005194 | 0.84 | ADORA1 (0.45) | CHEK1KCNH2RIPK1ADORA2AADORA1 | |
| SCHEMBL2999191 | 0.84 | HCAR3 (0.44) | CHEK1KCNH2CNR1RIPK1ADORA2A | |
| SCHEMBL3007636 | 0.84 | RIPK1 (0.40) | CHEK1KCNH2RIPK1ADORA2AADORA1 | |
| SCHEMBL3007638 | 0.83 | ADORA1 (0.46) | CHEK1KCNH2CNR1RIPK1ADORA2A | |
| SCHEMBL3013767 | 0.81 | CHEK1 (0.41) | CHEK1KCNH2CNR1RIPK1 | |
| SCHEMBL3755895 | 0.81 | ADORA1 (0.34) | CHEK1KCNH2CNR1RIPK1ADORA1 | |
| SCHEMBL3748032 | 0.81 | CHEK1 (0.37) | CHEK1KCNH2RIPK1ADORA2AADORA1 | |
| SCHEMBL3008980 | 0.81 | PLA2G1B (0.41) | CHEK1KCNH2MAPTPSMD14 | |
| SCHEMBL3008763 | 0.78 | POLB (0.50) | KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120270203-A1 | INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT | LG CHEM, LTD. (KR) | 2012-10-25 | — | — | US | disclosed |
| US-20100291533-A1 | INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT | LG LIFE SCIENCES LTD. (KR) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270203-A1 | INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT | IDO1, IDO2, INMT | CHEK1 1034/4885KCNH2 563/4885CNR1 1366/4885 |
| US-20100291533-A1 | INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT | IDO1, IDO2, INMT | CHEK1 1034/4885KCNH2 563/4885CNR1 1366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.