Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.61 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.61 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3748526 | 0.89 | KCNA5 (0.67) | PRMT5WDR77KCNA5ALDH1A1SCN9A | |
| SCHEMBL3750823 | 0.88 | PRMT5 (0.61) | PRMT5WDR77KCNA5ALDH1A1SCN9A | |
| SCHEMBL3756269 | 0.86 | KCNA5 (0.61) | PRMT5WDR77KCNA5ALDH1A1KCNH2 | |
| SCHEMBL3751608 | 0.86 | P2RX7 (0.61) | PRMT5WDR77KCNA5SCN9AKCNH2 | |
| SCHEMBL3762772 | 0.85 | SCN9A (0.56) | PRMT5WDR77KCNA5ALDH1A1SCN9A | |
| SCHEMBL3750421 | 0.84 | KCNA5 (0.55) | PRMT5WDR77KCNA5SCN9AKCNH2 | |
| SCHEMBL3750249 | 0.84 | KCNA5 (0.56) | PRMT5WDR77KCNA5ALDH1A1SCN9A | |
| SCHEMBL3750436 | 0.84 | ALDH1A1 (0.63) | PRMT5WDR77KCNA5ALDH1A1SCN9A | |
| SCHEMBL3762591 | 0.83 | KCNA5 (0.64) | PRMT5WDR77KCNA5ALDH1A1SCN9A | |
| SCHEMBL3750652 | 0.83 | SCN9A (0.60) | PRMT5WDR77KCNA5ALDH1A1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | claimed |
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | claimed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | claimed |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | US | claimed |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | ASTRAZENECA AB (SE) | 2010-11-25 | — | — | US | disclosed |
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |
| US-20080015237-A1 | NEW COMPOUNDS I/418 | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015237-A1 | NEW COMPOUNDS I/418 | KCNH1, KCNH2, KCNH3 | PRMT5 1341/4885WDR77 2402/4885KCNA5 69/4885 |
| US-20100298392-A1 | Isoindoline Derivatives For The Treatment Of Arrhythmias | KCNH1, KCNH2, KCNQ2 | PRMT5 683/4885WDR77 2954/4885KCNA5 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.