Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.61 |
| ▸ | RNASEH1 | O60930 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 3/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10084040 | 0.89 | PDE5A (0.59) | PDE5AKMT2APDE3BPDE3ACDC7 | |
| SCHEMBL10083509 | 0.89 | PDE5A (0.58) | PDE5AKMT2APDE3BPDE3ACDC7 | |
| SCHEMBL46289 | 0.89 | PDE5A (0.76) | PDE5AKMT2APDE3BPDE3ACDC7 | |
| SCHEMBL46291 | 0.86 | PDE5A (0.50) | PDE5AKMT2ACDC7CCNE1CDK2 | |
| SCHEMBL37513 | 0.86 | PDE5A (0.79) | PDE5ARNASEH1KMT2ACDC7CCNE1 | |
| SCHEMBL38484 | 0.85 | PDE5A (0.57) | PDE5ARNASEH1KMT2APDE3BPDE3A | |
| SCHEMBL46453 | 0.85 | KDM4E (0.50) | PDE5ACDC7CCNE1CDK2ROCK1 | |
| SCHEMBL46296 | 0.83 | PDE5A (0.56) | PDE5ARNASEH1KMT2APDE3BPDE3A | |
| SCHEMBL3491252 | 0.82 | PDE5A (0.61) | PDE5ARNASEH1KMT2APDE3BPDE3A | |
| SCHEMBL37583 | 0.79 | PDE5A (0.78) | PDE5ARNASEH1KMT2ACDC7CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |
| WO-2012004900-A1 | THIENOPYRIMIDINE COMPOUNDS | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-12 | — | — | WO | disclosed |