Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357083 | 1.00 | KDM4E (0.40) | KDM4EHTTTDP1MAPTALDH1A1 | |
| SCHEMBL2306361 | 1.00 | KDM4E (0.40) | KDM4EHTTTDP1MAPTALDH1A1 | |
| SCHEMBL2310406 | 0.86 | KDM4E (0.42) | KDM4EHTTTDP1MAPTALDH1A1 | |
| SCHEMBL17451277 | 0.77 | KDM4E (0.36) | KDM4EHTTTDP1MAPTALDH1A1 | |
| SCHEMBL2306871 | 0.75 | TSHR (0.41) | KDM4EHTTMAPTALDH1A1KMT2A | |
| SCHEMBL5014273 | 0.75 | TSHR (0.41) | KDM4EHTTMAPTALDH1A1KMT2A | |
| SCHEMBL2305986 | 0.75 | TSHR (0.41) | KDM4EHTTMAPTALDH1A1KMT2A | |
| SCHEMBL5011006 | 0.74 | KDM4E (0.39) | KDM4EHTTTDP1MAPTALDH1A1 | |
| SCHEMBL5014297 | 0.74 | KDM4E (0.36) | KDM4EHTTTDP1MAPTALDH1A1 | |
| SCHEMBL3069796 | 0.74 | KDM4E (0.38) | KDM4EHTTTDP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193132-A2 | 3-SPIROPYRIMIDINETRIONE-QUINOLINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | AstraZeneca AB (SE) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009004382-A2 | 3-SPIROPYRIMIDINETRIONE-QUINOLINE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2009-01-08 | — | — | WO | disclosed |