Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | MMP1 | P03956 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8417469 | 0.89 | MMP1 (0.65) | MMP1KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL8401704 | 0.87 | HDAC1 (0.89) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL1083553 | 0.84 | HDAC1 (0.73) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL28904178 | 0.84 | RAB9A (0.65) | MMP1KMT2ANPC1RAB9AMEN1 | |
| SCHEMBL1064052 | 0.84 | HDAC1 (0.68) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL10145965 | 0.84 | HDAC3 (0.66) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL12934325 | 0.82 | HDAC1 (0.64) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL1060598 | 0.82 | HDAC1 (0.79) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| Dinaline SCHEMBL93636 | 0.82 | HDAC1 (0.79) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| Dinaline SCHEMBL29354254 | 0.82 | HDAC1 (0.79) | HDAC1HDAC3HDAC2MAPK1NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211901-B2 | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-07-03 | — | — | US | disclosed |
| US-20100298358-A1 | Naphthamide Derivatives As Multi-Target Protein Kinase Inhibitors and Histone Deacetylase Inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2010-11-25 | — | — | US | disclosed |
| EP-0937711-A1 | Thiobenzamides, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1999-08-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298358-A1 | Naphthamide Derivatives As Multi-Target Protein Kinase Inhibitors and Histone Deacetylase Inhibitors | HDAC1, HDAC2, HDAC5 | HDAC1 1/4885HDAC3 7/4885HDAC2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.