Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4868297 | 1.00 | LMNA (0.39) | LMNASMN1; SMN2HTTBCHEACHE | |
| SCHEMBL3760788 | 0.93 | BCHE (0.44) | LMNASMN1; SMN2HTTBCHEACHE | |
| SCHEMBL5412549 | 0.87 | CA1 (0.38) | LMNASMN1; SMN2BCHEACHEALDH1A1 | |
| SCHEMBL5412252 | 0.87 | HSD11B1 (0.39) | LMNASMN1; SMN2HTTALDH1A1KMT2A | |
| Sulfuric Acid SCHEMBL2920577 | 0.86 | NPC1 (0.41) | LMNASMN1; SMN2ALDH1A1MAPK1NPC1 | |
| SCHEMBL51290 | 0.84 | TSHR (0.50) | LMNASMN1; SMN2HTTBCHEACHE | |
| SCHEMBL3755831 | 0.83 | CA1 (0.36) | LMNASMN1; SMN2BCHEACHEALDH1A1 | |
| Sulfuric Acid SCHEMBL2920580 | 0.83 | NPC1 (0.39) | LMNASMN1; SMN2MAPK1NPC1RAB9A | |
| Toliodium SCHEMBL2895871 | 0.82 | GAA (0.50) | LMNASMN1; SMN2ACHEALDH1A1MAPK1 | |
| SCHEMBL5412220 | 0.81 | HDAC8 (0.36) | LMNASMN1; SMN2MAPK1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225395-A1 | Thermally stable cationic photocurable compositions | WOLF JEAN-PIERRE | 2007-09-27 | — | — | US | claimed |
| US-20050165141-A1 | Thermally stable cationic photocurable compositions | CIBA SPECIALTY CHEMICALS CORP. | 2005-07-28 | — | — | US | claimed |
| EP-2076563-B1 | THERMALLY STABLE CATIONIC PHOTOCURABLE COMPOSITIONS | BASF SE (DE) | 2016-08-17 | — | — | EP | disclosed |
| US-8084522-B2 | Thermally stable cationic photocurable compositions | BASF SE (DE) | 2011-12-27 | — | — | US | disclosed |
| US-20100304284-A1 | THERMALLY STABLE CATIONIC PHOTOCURABLE COMPOSITIONS | IGM GROUP B.V. (NL) | 2010-12-02 | — | — | US | disclosed |
| EP-2076563-A1 | THERMALLY STABLE CATIONIC PHOTOCURABLE COMPOSITIONS | Ciba Holding Inc. (CH) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008049743-A1 | THERMALLY STABLE CATIONIC PHOTOCURABLE COMPOSITIONS | CIBA HOLDING INC. (CH) | 2008-05-02 | — | — | WO | disclosed |
| US-20070225395-A1 | Thermally stable cationic photocurable compositions | WOLF JEAN-PIERRE | 2007-09-27 | — | — | US | disclosed |
| EP-1709099-A2 | THERMALLY STABLE CATIONIC PHOTOCURABLE COMPOSITIONS | Ciba Specialty Chemicals Holding Inc. (CH) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005070989-A2 | THERMALLY STABLE CATIONIC PHOTOCURABLE COMPOSITIONS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2005-08-04 | — | — | WO | disclosed |
| US-20050165141-A1 | Thermally stable cationic photocurable compositions | CIBA SPECIALTY CHEMICALS CORP. | 2005-07-28 | — | — | US | disclosed |
| US-20010036591-A1 | Iodonium salts as latent acid donors | IGM GROUP B.V. (NL) | 2001-11-01 | — | — | US | disclosed |
| US-6306555-B1 | RADIATION-SENSITIVE COMPOSITION COMPRISING CATIONICALLY OR ACID-CATALYTICALLY POLYMERISABLE OR CROSSLINKABLE COMPOUND OR COMPOUND THAT INCREASES ITS SOLUBILITY IN DEVELOPER UNDER ACTION OF ACID, AND AT LEAST ONE DIARYLIODONIUM SALT | CIBA SPECIALTY CHEMICALS CORP. | 2001-10-23 | — | — | US | disclosed |