Sugi Predict

Sugi Predict / Compounds / SCHEMBL3756911

SCHEMBL3756911

SCHEMBL3756911

C[Si](C)(C)CNC(=O)C1c2ccccc2C(=O)N1Cc1ccc(Cl)c(Cl)c1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.55
▸ TP53 P04637 2/20 0.52
▸ CYP1A2 P05177 1/20 0.51
▸ POLB P06746 1/20 0.51
▸ CYP3A4 P08684 1/20 0.51
▸ CYP2D6 P10635 1/20 0.51
▸ CYP2C9 P11712 1/20 0.51
▸ P2RX7 Q99572 2/20 0.50
▸ GAA P10253 1/20 0.49
▸ PRMT5 O14744 2/20 0.48
▸ WDR77 Q9BQA1 2/20 0.48
▸ KCNA5 P22460 2/20 0.46
▸ KCNH2 Q12809 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3753429 0.84 SCN9A (0.58) ALDH1A1TP53P2RX7PRMT5WDR77
SCHEMBL3743693 0.81 KCNH2 (0.50) ALDH1A1TP53CYP1A2POLBCYP3A4
SCHEMBL3758510 0.81 ALDH1A1 (0.50) ALDH1A1TP53POLBKCNA5KCNH2
SCHEMBL3750779 0.80 SCN9A (0.49) ALDH1A1TP53CYP1A2POLBCYP3A4
SCHEMBL3755269 0.78 P2RX7 (0.55) TP53P2RX7KCNA5KCNH2
SCHEMBL3758533 0.78 P2RX7 (0.55) P2RX7KCNA5KCNH2
SCHEMBL3748868 0.77 ALDH1A1 (0.45) ALDH1A1TP53POLBP2RX7KCNA5
SCHEMBL3748881 0.76 SCN9A (0.64) ALDH1A1KCNA5KCNH2
SCHEMBL3750376 0.76 KCNA5 (0.54) ALDH1A1TP53POLBP2RX7PRMT5
SCHEMBL3756430 0.76 SCN9A (0.57) P2RX7KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100298392-A1 Isoindoline Derivatives For The Treatment Of Arrhythmias ASTRAZENECA AB (SE) 2010-11-25 — — US claimed
EP-2049484-A1 ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS AstraZeneca AB (SE) 2009-04-22 — — EP claimed
WO-2008008022-A1 ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS ASTRAZENECA AB (SE) 2008-01-17 — — WO claimed
US-20080015237-A1 NEW COMPOUNDS I/418 ASTRAZENECA AB (SE) 2008-01-17 — — US claimed
US-20100298392-A1 Isoindoline Derivatives For The Treatment Of Arrhythmias ASTRAZENECA AB (SE) 2010-11-25 — — US disclosed
EP-2049484-A1 ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS AstraZeneca AB (SE) 2009-04-22 — — EP disclosed
WO-2008008022-A1 ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS ASTRAZENECA AB (SE) 2008-01-17 — — WO disclosed
US-20080015237-A1 NEW COMPOUNDS I/418 ASTRAZENECA AB (SE) 2008-01-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080015237-A1 NEW COMPOUNDS I/418 KCNH1, KCNH2, KCNH3 ALDH1A1 315/4885TP53 3912/4885CYP1A2 8/4885
US-20100298392-A1 Isoindoline Derivatives For The Treatment Of Arrhythmias KCNH1, KCNH2, KCNQ2 ALDH1A1 310/4885TP53 3602/4885CYP1A2 27/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.