SCHEMBL3757571

SCHEMBL3757571

Brc1ccc(P(c2ccc(Br)cc2)c2ccc(Br)cc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.57
TDP1 Q9NUW8 2/20 0.44
CYP3A4 P08684 1/20 0.44
ALDH1A1 P00352 4/20 0.42
ALOX15 P16050 2/20 0.42
MAPK1 P28482 2/20 0.42
CA2 P00918 6/20 0.39
CA1 P00915 4/20 0.39
ESR1 P03372 2/20 0.39
ESR2 Q92731 2/20 0.39
PLCG1 P19174 1/20 0.38
TSHR P16473 1/20 0.36
CES2 O00748 1/20 0.36
CES1 P23141 1/20 0.36
CA12 O43570 1/20 0.35
CA9 Q16790 1/20 0.35
MMP1 P03956 1/20 0.35
MMP2 P08253 1/20 0.35
MMP9 P14780 1/20 0.35
MMP8 P22894 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2462689 0.88 TDP1 (0.67) CYP2A6TDP1CYP3A4ALDH1A1ALOX15
SCHEMBL739399 0.88 TDP1 (0.67) CYP2A6TDP1CYP3A4ALDH1A1ALOX15
SCHEMBL13429923 0.86 CYP2A6 (0.42) CYP2A6TDP1CYP3A4ALDH1A1ALOX15
SCHEMBL12440975 0.86 ALDH1A1 (0.68) CYP2A6TDP1CYP3A4ALDH1A1ALOX15
SCHEMBL14422419 0.84 CYP2C19 (0.48) CYP2A6CYP3A4ALDH1A1ESR1ESR2
SCHEMBL12514351 0.80 MEN1 (0.40) CYP2A6ALDH1A1CA2HTR2ATAAR1
SCHEMBL13430088 0.76 TAAR1 (0.45) CYP2A6CA2CA1CA12CA9
SCHEMBL4276353 0.76 CYP2A6 (0.53) CYP2A6TDP1ALDH1A1ALOX15MAPK1
SCHEMBL22583757 0.76 CYP2A6 (0.38) CYP2A6ALDH1A1ALOX15MAPK1CA2
SCHEMBL18508 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120081878-A Polynuclear metallocene complex, preparation method thereof, catalyst composition and application thereof 中国石油化工股份有限公司 2025-06-03 CN claimed
CN-119330838-A Method for directly heptafluoroisopropylating aromatic hydrocarbon by utilizing electron donor-acceptor compound strategy 浙江工业大学 2025-01-21 CN claimed
CN-119143613-A Preparation method of 2- (3-methyl-1-methylene butyl) aniline 浙江工业大学 2024-12-17 CN claimed
CN-116217386-B Carboxylic acid compound and preparation method and application thereof 五邑大学 2024-09-24 CN claimed
CN-118388585-A Preparation method of amide and ester compounds based on visible light catalysis 泰山学院 2024-07-26 CN claimed
CN-118290477-A Chiral fluorescent copper cluster material and preparation method thereof 江苏师范大学 2024-07-05 CN claimed
CN-116217386-A Carboxylic acid compound and preparation method and application thereof 五邑大学 2023-06-06 CN claimed
CN-112724373-B Functional organic porous polymer and preparation method and application thereof 山东大学 2021-09-21 CN claimed
CN-112724373-A Functional organic porous polymer and preparation method and application thereof 山东大学 2021-04-30 CN claimed
US-6608216-B2 Preparing biaryl atropisomers; chirality transfer from stereogenic center of secondary alcohol to biaryl stereogenic axis via regioselective intramolecular migration ABBOTT LABORATORIES 2003-08-19 US claimed
US-20030073844-A1 Process for the preparation of chiral glucocorticoid receptor agents ABBOTT LABORATORIES 2003-04-17 US claimed
WO-2003002548-A1 A PROCESS FOR THE PREPARATION OF CHIRAL GLUCOCORTICOID RECEPTOR AGENTS ABBOTT LABORATORIES (US) 2003-01-09 WO claimed
EP-0096905-B1 PROCESS FOR THE PREPARATION OF GLYCOL ALDEHYDE SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1986-04-23 EP claimed
EP-0096905-A1 Process for the preparation of glycol aldehyde SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1983-12-28 EP claimed
EP-4613256-A1 DENTAL ADHESIVE COMPOSITION Kuraray Noritake Dental Inc. (JP) 2025-09-10 EP disclosed
CN-120272152-A Ceramic tile adhesive with high bonding strength and preparation method thereof 斯科瑞新材料科技(山东)股份有限公司 2025-07-08 CN disclosed
US-20250186309-A1 DENTAL CURABLE COMPOSITION AND DENTAL KIT KURARAY NORITAKE DENTAL INC. (JP) 2025-06-12 US disclosed
US-4006185-A CHEMICAL INTERMEDIATES OLIN CORPORATION (US) 1977-02-01 US disclosed
US-3965183-A FROM M-NITROACETANILIDE WITH HYDROGEN FLUORIDE OLIN CORPORATION (US) 1976-06-22 US disclosed
US-3953510-A Method for the preparation of alkoxyanilines OLIN CORPORATION (US) 1976-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030073844-A1 Process for the preparation of chiral glucocorticoid receptor agents NR3C1, NR3C2, MC2R CYP2A6 162/4885TDP1 4823/4885CYP3A4 98/4885
US-20250186309-A1 DENTAL CURABLE COMPOSITION AND DENTAL KIT KIT, DNMT3L, CDK6 CYP2A6 4449/4885TDP1 1753/4885CYP3A4 4581/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.