⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3751377 | 0.73 | NPY5R (0.41) | — | |
| SCHEMBL3754790 | 0.72 | NPY5R (0.43) | — | |
| SCHEMBL3758771 | 0.72 | CHRNA7 (0.33) | — | |
| SCHEMBL3769533 | 0.70 | HTR6 (0.49) | — | |
| SCHEMBL3754803 | 0.70 | NCF1 (0.44) | — | |
| SCHEMBL3996914 | 0.68 | SRD5A1 (0.38) | — | |
| SCHEMBL3766056 | 0.64 | ADORA2A (0.31) | — | |
| SCHEMBL3761781 | 0.63 | ALDH1A1 (0.33) | — | |
| SCHEMBL3763849 | 0.63 | MAPT (0.38) | — | |
| SCHEMBL3757720 | 0.61 | TDO2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029570-B1 | FUSED THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA SA (BE) | 2014-10-15 | — | — | EP | disclosed |
| US-8324204-B2 | Fused thiophene derivatives as kinase inhibitors | UCB PHARMA SA (BE) | 2012-12-04 | — | — | US | disclosed |
| US-20100305066-A1 | Fused Thiophene Derivatives as Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2010-12-02 | — | — | US | disclosed |
| WO-2009071895-A1 | FUSED THIAZOLE AND THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009071890-A1 | TRICYCLIC KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2009-06-11 | — | — | WO | disclosed |