Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 7/20 | 0.44 |
| ▸ | CA2 | P00918 | 7/20 | 0.44 |
| ▸ | CA9 | Q16790 | 5/20 | 0.44 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5188402 | 0.88 | CDK2 (0.48) | CDK2GSK3BCA1CA2CA9 | |
| SCHEMBL5143187 | 0.87 | CDK2 (0.47) | CDK2GSK3BCA1CA2CA9 | |
| SCHEMBL5189038 | 0.87 | CDK2 (0.48) | CDK2GSK3BCA1CA2CA9 | |
| SCHEMBL5147453 | 0.71 | KCNH2 (0.42) | CDK2MEN1KMT2APOLBKDM4E | |
| SCHEMBL5735124 | 0.70 | ALDH1A1 (0.50) | ALDH1A1GAAHPGD | |
| SCHEMBL445807 | 0.70 | CA2 (0.53) | CDK2GSK3BCA1CA2CA9 | |
| SCHEMBL26054607 | 0.66 | KDM4E (0.54) | CDK2GSK3BCA1CA2CA9 | |
| SCHEMBL21067359 | 0.64 | CDK2 (1.00) | CDK2GSK3BMEN1KMT2APOLB | |
| SCHEMBL18891690 | 0.62 | ALDH1A1 (0.60) | GSK3BCA1CA2CA9CA12 | |
| SCHEMBL308881 | 0.62 | CA2 (1.00) | CA1CA2CA9CA12CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120289569-A1 | INHIBITORS OF UBIQUITIN E1 | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-11-15 | — | — | US | disclosed |
| US-8242160-B2 | Inhibitors of ubiquitin E1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-08-14 | — | — | US | disclosed |
| US-20100305180-A1 | INHIBITORS OF UBIQUITIN E1 | WEISSMAN ALLAN M | 2010-12-02 | — | — | US | disclosed |
| US-20080306130-A1 | Inhibitors of ubiquitin E1 | GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306130-A1 | Inhibitors of ubiquitin E1 | CUL1, UBQLN1, UBE2E1 | CDK2 203/4885GSK3B 1606/4885CA1 3812/4885 |
| US-20120289569-A1 | INHIBITORS OF UBIQUITIN E1 | CUL1, UBQLN1, UBE2E1 | CDK2 203/4885GSK3B 1606/4885CA1 3812/4885 |
| US-20100305180-A1 | INHIBITORS OF UBIQUITIN E1 | CUL1, UBQLN1, UBE2E1 | CDK2 203/4885GSK3B 1606/4885CA1 3812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.