Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | UBE2M | P61081 | 3/20 | 0.47 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3485824 | 0.86 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2HSD17B10RECQL | |
| SCHEMBL3485918 | 0.85 | TSHR (0.56) | ALDH1A1LMNASMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL3485705 | 0.85 | ALDH1A1 (0.54) | ALDH1A1LMNASMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL3485688 | 0.85 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL3485300 | 0.83 | SMN1; SMN2 (0.52) | ALDH1A1LMNASMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL3484989 | 0.83 | RORC (0.55) | ALDH1A1LMNASMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL3485926 | 0.83 | CACNA1B (0.53) | ALDH1A1LMNASMN1; SMN2HSD17B10UBE2M | |
| SCHEMBL3485265 | 0.81 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL3485489 | 0.81 | L3MBTL1 (0.51) | ALDH1A1LMNASMN1; SMN2HSD17B10UBE2M | |
| SCHEMBL3486183 | 0.80 | LMNA (0.48) | ALDH1A1LMNASMN1; SMN2HSD17B10RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765736-B2 | Benzenesulfonamide compounds and the use thereof | PURDUE PHARMA L.P. (US) | 2014-07-01 | — | — | US | claimed |
| US-20100311792-A1 | Benzenesulfonamide Compounds and the Use Thereof | PURDUE PHARMA L.P. | 2010-12-09 | — | — | US | claimed |
| US-8765736-B2 | Benzenesulfonamide compounds and the use thereof | PURDUE PHARMA L.P. (US) | 2014-07-01 | — | — | US | disclosed |
| US-20100311792-A1 | Benzenesulfonamide Compounds and the Use Thereof | PURDUE PHARMA L.P. | 2010-12-09 | — | — | US | disclosed |
| WO-2009040659-A2 | BENZENESULFONAMIDE COMPOUNDS AND THE USE THEREOF | PURDUE PHARMA L.P. (DE) | 2009-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311792-A1 | Benzenesulfonamide Compounds and the Use Thereof | CACNA1A, CACNA1E, CACNA1B | ALDH1A1 1954/4885LMNA 2734/4885SMN1; SMN2 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.