Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.34 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6966310 | 0.87 | KCNH2 (0.36) | KCNH2ALDH1A1MAPK1MAPTHPGD | |
| SCHEMBL5195567 | 0.85 | ALDH1A1 (0.43) | KCNH2ALDH1A1MAPK1MAPTHPGD | |
| SCHEMBL6970166 | 0.85 | SOAT2 (0.37) | KCNH2ALDH1A1MAPK1SMN1; SMN2LMNA | |
| SCHEMBL5077126 | 0.84 | SOAT2 (0.40) | MAPK1SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL5144120 | 0.84 | SOAT2 (0.40) | MAPK1SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL5145612 | 0.84 | SOAT2 (0.40) | MAPK1SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL3071242 | 0.81 | ALDH1A1 (0.40) | KCNH2ALDH1A1MAPK1MAPTHPGD | |
| SCHEMBL5167477 | 0.81 | ALDH1A1 (0.40) | KCNH2ALDH1A1MAPK1MAPTHPGD | |
| SCHEMBL11647478 | 0.78 | ALDH1A1 (0.40) | KCNH2ALDH1A1MAPK1MAPTHPGD | |
| SCHEMBL9347870 | 0.77 | ALDH1A1 (0.37) | KCNH2ALDH1A1MAPK1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543919-B1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS IN THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF CNS DISEASES | SEARLE & CO (US) | 1996-04-10 | — | — | EP | claimed |
| EP-0543919-A1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS FOR TREATMENT OF CNS DISEASES. | SEARLE & CO (US) | 1993-06-02 | — | — | EP | claimed |
| US-5120849-A | Reacting cyclic imidoether with aminoalcohol | BASF AKTIENGESELLSCHAFT (DE) | 1992-06-09 | — | — | US | claimed |
| WO-1992003131-A1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS FOR TREATMENT OF CNS DISEASES | G.D. SEARLE & CO. (US) | 1992-03-05 | — | — | WO | claimed |
| US-20100298370-A1 | BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF | RIMONYX PHARMACEUTICALS LTD. (IL) | 2010-11-25 | — | — | US | disclosed |
| WO-2008020438-A2 | BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF | RIMONYX PHARMACEUTICALS LTD (IL) | 2008-02-21 | — | — | WO | disclosed |
| WO-2007119600-A1 | CARBAZOLE COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-10-25 | — | — | WO | disclosed |
| US-6673886-B2 | FOR INTRAOCULAR LENSES | BAUSCH & LOMB INCORPORATED | 2004-01-06 | — | — | US | disclosed |
| US-6657029-B2 | High refractive index monomer, greater amount of a hydrophilic monomer, crosslinker, and initiator; give water content; intraocular lenses | BAUSCH & LOMB INCORPORATED | 2003-12-02 | — | — | US | disclosed |
| US-6657032-B2 | High refractive index and hydrophilic monomers, a crosslinker, an initiator and water | BAUSCH & LOMB INCORPORATED | 2003-12-02 | — | — | US | disclosed |
| US-6657030-B2 | High refractive index and hydrophilic monomers, a crosslinker, an initiator and water | BAUSCH & LOMB INCORPORATED | 2003-12-02 | — | — | US | disclosed |
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |
| EP-0099172-A1 | 6,7-Dihydro-7,7-disubstituted-khellins | THE UPJOHN COMPANY (US) | 1984-01-25 | — | — | EP | disclosed |
| EP-0095836-A1 | Aza-furochromones | THE UPJOHN COMPANY (US) | 1983-12-07 | — | — | EP | disclosed |
| US-4412071-A | Antiatherosclerotic compositions | THE UPJOHN COMPANY (US) | 1983-10-25 | — | — | US | disclosed |
| US-4393070-A | HYPOTENSIVE, VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-07-12 | — | — | US | disclosed |
| US-4307103-A | TREATMENT OF HYPERTENSION AND CARDIOVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-12-22 | — | — | US | disclosed |
| US-4304718-A | ANTIBIOTICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-12-08 | — | — | US | disclosed |
| US-4264498-A | REACTED WITH AN ACID, ITS ACID HALIDE, OR ANHYDRIDE IN THE PRESENCE OF BORON TRIHALIDE AND AN ORGANIC BASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-04-28 | — | — | US | disclosed |
| US-4181800-A | ANTIBIOTICS FROM SUBSTITUTED PERHYDRO-S-TRIAZINES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1980-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298370-A1 | BENZOTHIAZOLYL THIENOPYRIDINE DERIVATIVES AND USES THEREOF | HPSE, HDGF, HPGDS | KCNH2 3401/4885ALDH1A1 1539/4885MAPK1 1021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.