Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL6535103 | 0.93 | ALDH1A1 (0.37) | ALDH1A1 | |
| Ether SCHEMBL40006 | 0.93 | — | — | |
| Ether SCHEMBL28855718 | 0.93 | ALDH1A1 (0.37) | ALDH1A1 | |
| Ether SCHEMBL9009598 | 0.93 | ALDH1A1 (0.37) | ALDH1A1 | |
| Ether SCHEMBL28468835 | 0.90 | ALDH1A1 (0.45) | ALDH1A1TSHR | |
| Ether SCHEMBL23704984 | 0.89 | ALDH1A1 (0.35) | ALDH1A1 | |
| Ether SCHEMBL16446730 | 0.89 | ALDH1A1 (0.35) | ALDH1A1 | |
| Ether SCHEMBL2428958 | 0.86 | — | — | |
| Ether SCHEMBL10683113 | 0.86 | ALDH1A1 (0.33) | ALDH1A1 | |
| Ether SCHEMBL4526541 | 0.86 | ALDH1A1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE45128-E1 | Cephalotaxane derivatives and their processes of preparation and purification | IVAX International GmbH (CH) | 2014-09-09 | — | — | US | disclosed |
| US-7842687-B2 | Natural, synthetic or semi-synthetic crude harringtonines purified by chromatography and crystallization in which the solvent is water or lower C1-4 alkanol or an aqueous mixture of organic solvents; treatment of cancer through oral administration | CHEMGENEX PHARMACEUTICALS, INC. (AU) | 2010-11-30 | — | — | US | disclosed |
| US-7169774-B2 | Cephalotaxane derivatives and their processes of preparation and purification | STRAGEN PHARMA S.A. (CH) | 2007-01-30 | — | — | US | disclosed |
| US-20060234999-A1 | Cephalotaxane derivatives and their processes of preparation and purification | TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) | 2006-10-19 | — | — | US | disclosed |
| US-20050090484-A1 | Cephalotaxane derivatives and their processes of preparation and purification | IVAX International GmbH (CH) | 2005-04-28 | — | — | US | disclosed |
| EP-1064285-B1 | NOVEL CEPHALOTAXANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | STRAGEN PHARMA SA (CH) | 2005-02-16 | — | — | EP | disclosed |
| US-6831180-B1 | Substituted tertiary carboxylic oxacycloalkane acids, used to prepare anhydro-homo-harringtonic acids by semi-synthesis; hydroxyl function of a cephalotaxane is esterified with a 2-carboxyl-2-alkyl-1-oxacycloalkane claimed intermediate; (indexing from 7169774 added) | STRAGEN PHARMA SA. (CH) | 2004-12-14 | — | — | US | disclosed |
| US-6613900-B2 | Asymetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. | ONCOPHARM CORPORATION | 2003-09-02 | — | — | US | disclosed |
| US-20020045750-A1 | Asymetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. | IVAX International GmbH (CH) | 2002-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060234999-A1 | Cephalotaxane derivatives and their processes of preparation and purification | UGT1A7, CYP8B1, UGT2B7 | ALDH1A1 1136/4885TSHR 2148/4885 |
| US-20020045750-A1 | Asymetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. | AAAS, AARS1, AADAT | ALDH1A1 804/4885TSHR 3354/4885 |
| US-20050090484-A1 | Cephalotaxane derivatives and their processes of preparation and purification | UGT1A7, CYP8B1, UGT2B7 | ALDH1A1 1136/4885TSHR 2148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.