Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6733638 | 0.98 | MEN1 (0.52) | MEN1KMT2ACYP4F2CYP4A11ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL8176760 | 0.83 | CYP4F2 (0.59) | MEN1KMT2ACYP4F2CYP4A11ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL49875 | 0.81 | CYP4F2 (0.61) | MEN1KMT2ACYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL21772025 | 0.80 | MEN1 (0.36) | MEN1KMT2ACYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL11710012 | 0.79 | MEN1 (0.68) | MEN1KMT2ACYP4F2CYP4A11ALDH1A1 | |
| Bromide SCHEMBL25233680 | 0.79 | CYP4F2 (0.59) | MEN1KMT2ACYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL15353342 | 0.79 | MEN1 (0.49) | MEN1KMT2ACYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL15353347 | 0.79 | MEN1 (0.49) | MEN1KMT2ACYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL444076 | 0.79 | CYP4F2 (0.63) | MEN1KMT2ACYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL1315228 | 0.78 | CYP4F2 (0.50) | MEN1KMT2ACYP4F2CYP4A11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076606-B1 | 2'-TERMINATOR RELATED PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION | ROCHE DIAGNOSTICS GMBH (DE) | 2012-01-25 | — | — | EP | disclosed |
| US-7928207-B2 | use of 2'-terminator nucleotides to effect chain termination; kits; incubating a template nucleic acid with a nucleotide incorporating biocatalyst, and a 2'-terminator nucleotide | ROCHE MOLECULAR SYSTEMS, INC (US) | 2011-04-19 | — | — | US | disclosed |
| US-7745125-B2 | 2′-terminator related pyrophosphorolysis activated polymerization | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2010-06-29 | — | — | US | disclosed |
| US-20070219361-A1 | Synthesis and compositions of nucleic acids comprising 2'-terminator nucleotides | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2007-09-20 | — | — | US | disclosed |
| US-20070154914-A1 | 2'-Terminator related pyrophosphorolysis activated polymerization | ROCHE MOLECULAR SYSTEMS, INC. (US) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219361-A1 | Synthesis and compositions of nucleic acids comprising 2'-terminator nucleotides | RNGTT, POLRMT, NT5C3B | MEN1 2904/4885KMT2A 1483/4885CYP4F2 2148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.