Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetohexamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.62 |
| ▸ | PPARG | P37231 | 3/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetohexamide SCHEMBL15669221 | 1.00 | ALDH1A1 (1.00) | ALDH1A1LMNATHRBTSHRBLM | |
| Glyoctamide SCHEMBL667731 | 0.86 | ADORA3 (1.00) | ALDH1A1LMNATHRBTSHRBLM | |
| Glycyclamide SCHEMBL49386 | 0.86 | ADORA3 (1.00) | ALDH1A1LMNATHRBTSHRBLM | |
| Heptolamide SCHEMBL1814750 | 0.86 | ADORA3 (1.00) | ALDH1A1LMNATHRBTSHRBLM | |
| Acetohexamide SCHEMBL20267964 | 0.86 | ALDH1A1 (0.73) | ALDH1A1LMNATHRBTSHRBLM | |
| Acetohexamide SCHEMBL14660013 | 0.85 | ALDH1A1 (0.72) | ALDH1A1LMNATHRBTSHRBLM | |
| Glycyclamide SCHEMBL21722119 | 0.84 | ADORA3 (0.97) | ALDH1A1LMNATHRBTSHRBLM | |
| Tolpentamide SCHEMBL2109411 | 0.84 | ADORA3 (0.97) | ALDH1A1LMNATHRBTSHRBLM | |
| Acetohexamide SCHEMBL621658 | 0.84 | ALDH1A1 (0.72) | ALDH1A1LMNATHRBTSHRBLM | |
| SCHEMBL24162711 | 0.83 | PPARG (0.76) | ALDH1A1LMNATHRBTSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 19545 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260130854-A1 | PREPARATION OF NANO LINIMENT FOR EXTERNAL TREATMENT OF GOUT | Zhang, Boke (US) | 2026-05-14 | — | — | US | claimed |
| US-20260130853-A1 | METHOD OF TREATING GOUT BY TOPICAL APPLICATION OF NANO LINIMENT | Zhang, Boke (US) | 2026-05-14 | — | — | US | claimed |
| US-20260124282-A1 | DECORIN FOR ITS USE IN THE TREATMENT OF DIABETES | CENTRE EUROPEEN D'ETUDE DU DIABETE (FR) | 2026-05-07 | — | — | US | claimed |
| EP-4705280-A1 | DIARYL UREA-BASED COMPOUNDS AND RELATED COMPOSITIONS AND METHODS OF USE IN THE TREATMENT OF DIABETES MELLITUS AND NEURODEGENERATIVE DISEASE | Purdue Research Foundation (US) | 2026-03-11 | — | — | EP | claimed |
| US-12539273-B2 | External nano liniment for gout and preparation method thereof | Zhang, Boke (US) | 2026-02-03 | — | — | US | claimed |
| EP-4684799-A2 | ANTIBODIES THAT DISRUPT THE INTERACTION OF GAL3 AND INSULIN RECEPTOR OR INTEGRINS AND METHODS OF USE THEREOF | TrueBinding, Inc. (US) | 2026-01-28 | — | — | EP | claimed |
| US-12508301-B2 | Decorin for its use in the treatment of diabetes | CENTRE EUROPEEN D'ETUDE DU DIABETE (FR) | 2025-12-30 | — | — | US | claimed |
| EP-4656588-A2 | ENHANCED NANOPARTICLE DELIVERY SYSTEMS | Children's Hospital Medical Center (US) | 2025-12-03 | — | — | EP | claimed |
| US-20250340879-A1 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID TRANSFER | CHILDRENS HOSPITAL MED CT (US) | 2025-11-06 | — | — | US | claimed |
| EP-4640701-A2 | GLUCAGON LIKE PEPTIDE 1 (GLP-1) FUSION PEPTIDE COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE CONJUGATES AND USES THEREOF | Janssen Sciences Ireland Unlimited Company (IE) | 2025-10-29 | — | — | EP | claimed |
| CN-87103409-A | Preparation of solid pharmaceutical dosage forms | — | 1987-12-09 | — | — | CN | claimed |
| EP-0091193-B1 | ANTIDIABETIC COMPOSITIONS | PFIZER INC. (US) | 1986-05-21 | — | — | EP | claimed |
| EP-0126684-A2 | Drug delivery system utilizing thermosetting gels | MERCK & CO. INC. (US) | 1984-11-28 | — | — | EP | claimed |
| US-4478822-A | Drug delivery system utilizing thermosetting gels | MERCK & CO., INC. (US) | 1984-10-23 | — | — | US | claimed |
| US-4474752-A | DIAMINE MODIFIED POLYOXYETHYLENE-POLYOXYPROPYLENE COPOLYMER | MERCK & CO., INC. (US) | 1984-10-02 | — | — | US | claimed |
| EP-0091193-A2 | Antidiabetic compositions | PFIZER INC. (US) | 1983-10-12 | — | — | EP | claimed |
| US-4346709-A | Drug delivery devices comprising erodible polymer and erosion rate modifier | ALZA CORPORATION (US) | 1982-08-31 | — | — | US | claimed |
| US-4254109-A | INHIBIT LENS ALDOSE REDUCTASE | AYERST, MCKENNA & HARRISON INC. (CA) | 1981-03-03 | — | — | US | claimed |
| US-4254108-A | ALDOSE REDUCTASE INHIBITORS | AYERST, MCKENNA & HARRISON INC. (CA) | 1981-03-03 | — | — | US | claimed |
| US-4131652-A | Medicinal skin cream for psoriasis and method | DELUCCIA CHARLES R | 1978-12-26 | — | — | US | claimed |