Glycyclamide

Glycyclamide

SCHEMBL49386

Cc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 1/20 1.00
ALDH1A1 P00352 5/20 0.75
TSHR P16473 3/20 0.75
LMNA P02545 3/20 0.75
THRB P10828 1/20 0.75
BLM P54132 1/20 0.75
TDP1 Q9NUW8 1/20 0.75
GAA P10253 2/20 0.72
KCNH2 Q12809 1/20 0.72
HTT P42858 1/20 0.64
HSD17B10 Q99714 1/20 0.64
CYP3A4 P08684 2/20 0.63
NPC1 O15118 1/20 0.60
RAB9A P51151 1/20 0.60
EPHX1 P07099 1/20 0.60
KDM4E B2RXH2 1/20 0.59
TP53 P04637 1/20 0.59
GLA P06280 1/20 0.59
MAPT P10636 1/20 0.59
ALOX12 P18054 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glyoctamide SCHEMBL667731 1.00 ADORA3 (1.00) ADORA3ALDH1A1TSHRLMNATHRB
Heptolamide SCHEMBL1814750 1.00 ADORA3 (1.00) ADORA3ALDH1A1TSHRLMNATHRB
Glycyclamide SCHEMBL21722119 0.99 ADORA3 (0.97) ADORA3ALDH1A1TSHRLMNATHRB
Tolpentamide SCHEMBL2109411 0.98 ADORA3 (0.97) ADORA3ALDH1A1TSHRLMNATHRB
SCHEMBL5931113 0.87 ADORA3 (0.77) ADORA3ALDH1A1TSHRLMNATHRB
Acetohexamide SCHEMBL15669221 0.86 ALDH1A1 (1.00) ADORA3ALDH1A1TSHRLMNATHRB
Acetohexamide SCHEMBL37620 0.86 ALDH1A1 (1.00) ADORA3ALDH1A1TSHRLMNATHRB
SCHEMBL24162711 0.85 PPARG (0.76) ADORA3ALDH1A1TSHRLMNATHRB
SCHEMBL23007557 0.85 ADORA3 (0.74) ADORA3ALDH1A1TSHRLMNATHRB
SCHEMBL23736042 0.85 ADORA3 (0.74) ADORA3ALDH1A1TSHRLMNATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2038 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12208071-B2 Glucagon receptor antagonists LIGAND PHARMACEUTICALS INCORPORATED (US) 2025-01-28 US claimed
US-12186329-B2 Compositions and methods related to cholic acid 7-sulfate as a treatment for diabetes PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2025-01-07 US claimed
US-20240316048-A1 Prevention of Pancreatic Cell Degeneration MELIOR PHARMACEUTICALS I, INC. 2024-09-26 US claimed
US-12070461-B2 Methods and formulations for modulating Lyn kinase activity and treating related disorders MELIOR PHARMACEUTICALS I, INC. (US) 2024-08-27 US claimed
EP-4232448-A1 AGONISTS OF FREE FATTY ACID RECEPTOR 1 AND THEIR USE IN DISEASES ASSOCIATED WITH SAID RECEPTOR Halo Therapeutics Ltd (GB) 2023-08-30 EP claimed
US-20230263821-A1 Treatment Of Increased Lipid Levels With Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1) Inhibitors UNIVERSITY OF MARYLAND, BALTIMORE 2023-08-24 US claimed
CN-115799599-A Preparation method of in-situ cured soft package battery and in-situ cured soft package battery 上海空间电源研究所 2023-03-14 CN claimed
US-20220184070-A1 LOW-DOSE TRIPLE COMBINATION FORMULATION The George Institute for Global Health (AU) 2022-06-16 US claimed
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
WO-2022083853-A1 AGONISTS OF FREE FATTY ACID RECEPTOR 1 AND THEIR USE IN DISEASES ASSOCIATED WITH SAID RECEPTOR GBIOTECH S.À.R.L. (CH) 2022-04-28 WO claimed
US-6150383-A COMPRISING AN INSULIN SENSITIVITY ENHANCER IN COMBINATION WITH ONE OR MORE OTHER ANTIDIABETICS DIFFERING FROM THE ENHANCER IN MECHANISM OF ACTION; LIPID/GLYCOMETABOLISM DISORDERS; ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-11-21 US claimed
CN-1264302-A Treatment of diabetes with thiazolidinediones and sulfonylureas SMITHKLINE BEECHAM PLC (GB) 2000-08-23 CN claimed
CN-1263467-A Treatment of diabetes with thiazolidinedione, insulin secretagogue and alpha glucocidase inhibitor SMITHKLINE BEECHAM PLC (GB) 2000-08-16 CN claimed
WO-2000027401-A1 COMBINATIONS FOR DIABETES WHICH CONTAIN A SULFONYLUREA, A GLITAZONE AND A BIGUANIDE WARNER-LAMBERT COMPANY (US) 2000-05-18 WO claimed
CN-1244801-A Sulfonylurea-glitazone synergistic combinations for diabetes WARNER LAMBERT CO (US) 2000-02-16 CN claimed
US-6011049-A Combinations for diabetes WARNER-LAMBERT COMPANY (US) 2000-01-04 US claimed
EP-0957923-A1 SULFONYLUREA-GLITAZONE SYNERGISTIC COMBINATIONS FOR DIABETES WARNER-LAMBERT COMPANY (US) 1999-11-24 EP claimed
US-5972973-A SYNERGISTIC MIXTURE; GLUCOSE CONTROL WARNER-LAMBERT COMPANY (US) 1999-10-26 US claimed
US-5859037-A MIXTURE SYNERGISTIC FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS IN HUMANS, WHICH ALSO IMPROVES GLYCEMIC CONTROL WARNER-LAMBERT COMPANY (US) 1999-01-12 US claimed
WO-1998036755-A1 SULFONYLUREA-GLITAZONE SYNERGISTIC COMBINATIONS FOR DIABETES WARNER LAMBERT COMPANY (US) 1998-08-27 WO claimed