Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3762404 | 1.00 | MEN1 (0.44) | MEN1KMT2ALRRK2MAOAMAOB | |
| SCHEMBL3762412 | 1.00 | MEN1 (0.44) | MEN1KMT2ALRRK2MAOAMAOB | |
| SCHEMBL15619245 | 0.85 | ALDH1A1 (0.51) | MEN1KMT2ALRRK2ALDH1A1MAPT | |
| SCHEMBL15619244 | 0.85 | ALDH1A1 (0.51) | MEN1KMT2ALRRK2ALDH1A1MAPT | |
| Isoindigo SCHEMBL9899736 | 0.78 | LRRK2 (0.67) | LRRK2MAOAMAOBPDGFRAFER | |
| Isoindigo SCHEMBL9899740 | 0.78 | LRRK2 (0.67) | LRRK2MAOAMAOBPDGFRAFER | |
| Isoindigo SCHEMBL12386233 | 0.78 | LRRK2 (0.67) | LRRK2MAOAMAOBPDGFRAFER | |
| Isoindigo SCHEMBL29349649 | 0.78 | LRRK2 (0.67) | LRRK2MAOAMAOBPDGFRAFER | |
| SCHEMBL2589274 | 0.71 | LRRK2 (0.57) | MEN1KMT2ALRRK2MAOAMAOB | |
| SCHEMBL2589272 | 0.71 | LRRK2 (0.57) | MEN1KMT2ALRRK2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-02 | — | — | US | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | MEN1 3665/4885KMT2A 3767/4885LRRK2 4731/4885 |
| US-20100305121-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | FADS2, ACOT7, FADS1 | MEN1 3665/4885KMT2A 3767/4885LRRK2 4731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.