Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11891661 | 0.85 | RAB9A (0.60) | GAAKDM4EALDH1A1LMNARAB9A | |
| SCHEMBL28815311 | 0.80 | KDM4E (0.57) | KDM4EGLAALDH1A1MAPK1STAT3 | |
| SCHEMBL2988492 | 0.77 | KDM4E (0.51) | KDM4EGLAALDH1A1MAPK1STAT3 | |
| SCHEMBL1194101 | 0.76 | THRA (0.49) | KDM4EGLAALDH1A1MAPK1STAT3 | |
| SCHEMBL1054882 | 0.75 | GAA (0.45) | GAAKDM4EPTGDR2 | |
| SCHEMBL13224503 | 0.75 | KDM4E (0.49) | KDM4EGLAALDH1A1MAPK1STAT3 | |
| SCHEMBL2979855 | 0.73 | CCR2 (0.52) | KDM4EGLAALDH1A1MAPK1STAT3 | |
| SCHEMBL3561181 | 0.71 | PTGDR2 (0.53) | KDM4EGLAALDH1A1MAPK1STAT3 | |
| SCHEMBL3067363 | 0.70 | L3MBTL1 (0.64) | KDM4EALDH1A1SMN1; SMN2RAB9AHTT | |
| SCHEMBL27847165 | 0.70 | KDM4E (0.47) | KDM4EGLAALDH1A1MAPK1STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451780-B1 | INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF 4-(ACETYLAMINO))-3-[(4-CHLORO-PHENYL)THIO]-2-METHYL-1H-INDOLE-1-ACETIC ACID | ASTRAZENECA AB (SE) | 2013-06-19 | — | — | EP | disclosed |
| EP-2451780-A1 | INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF 4- (ACETYLAMINO) ) -3- [ (4-CHLORO-PHENYL) THIO]-2-METHYL-1H-INDOLE-1-ACETIC ACID | AstraZeneca AB (SE) | 2012-05-16 | — | — | EP | disclosed |