Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.91 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.89 |
| ▸ | MAPT | P10636 | 6/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.84 |
| ▸ | HPGD | P15428 | 1/20 | 0.84 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.84 |
| ▸ | MEN1 | O00255 | 2/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.81 |
| ▸ | THRB | P10828 | 1/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3760191 | 0.88 | MAPT (1.00) | TP53TDP1MAPTALDH1A1HPGD | |
| SCHEMBL7673829 | 0.84 | POLB (1.00) | TP53TDP1MAPTALDH1A1MEN1 | |
| SCHEMBL7663455 | 0.81 | ALDH1A1 (1.00) | TP53TDP1MAPTALDH1A1HPGD | |
| SCHEMBL7674766 | 0.80 | POLB (0.89) | TP53TDP1MAPTALDH1A1NPSR1 | |
| SCHEMBL7669974 | 0.79 | ALDH1A1 (0.84) | TP53TDP1MAPTALDH1A1HPGD | |
| SCHEMBL7674392 | 0.79 | POLB (0.84) | TP53TDP1MAPTALDH1A1HPGD | |
| SCHEMBL7669890 | 0.79 | ALDH1A1 (1.00) | TP53TDP1MAPTALDH1A1HPGD | |
| SCHEMBL7669650 | 0.79 | POLB (0.81) | TP53TDP1MAPTALDH1A1HPGD | |
| SCHEMBL7699135 | 0.78 | MAPT (0.81) | TP53TDP1MAPTALDH1A1HPGD | |
| SCHEMBL3756898 | 0.78 | POLB (0.84) | TP53TDP1MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305105-A1 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-12-02 | — | — | US | claimed |
| WO-2008061248-A2 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-05-22 | — | — | WO | claimed |
| US-8394788-B2 | Phenylsulfoxyoxazole compound inhibitors of urea transporters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-12 | — | — | US | disclosed |
| US-8394788-B2 | Phenylsulfoxyoxazole compound inhibitors of urea transporters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-12 | — | — | US | disclosed |
| US-8394788-B2 | Phenylsulfoxyoxazole compound inhibitors of urea transporters | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-03-12 | — | — | US | disclosed |
| US-20100305105-A1 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305105-A1 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100305105-A1 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-12-02 | — | — | US | disclosed |
| WO-2008061248-A2 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008061248-A2 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305105-A1 | PHENYLSULFOXYOXAZOLE COMPOUND INHIBITORS OF UREA TRANSPORTERS | SLC14A1, SLCO4C1, SLCO2B1 | TP53 3827/4885TDP1 3690/4885MAPT 584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.