Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.79 |
| ▸ | MEN1 | O00255 | 3/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.79 |
| ▸ | MAPT | P10636 | 6/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | HTT | P42858 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 4/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663455 | 0.89 | ALDH1A1 (1.00) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7673829 | 0.82 | POLB (1.00) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7665352 | 0.81 | ALDH1A1 (0.84) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7669974 | 0.81 | ALDH1A1 (0.84) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7669890 | 0.81 | ALDH1A1 (1.00) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3766151 | 0.79 | TP53 (0.91) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7674766 | 0.77 | POLB (0.89) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3756887 | 0.77 | TP53 (1.00) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL7669051 | 0.77 | HTR6 (0.78) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3755285 | 0.76 | L3MBTL1 (0.81) | POLBALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002100842-A1 | SULFONYLOXAZOLAMINES AND THEIR USE AS 5-HT6 LIGANDS | MERCK PATENT GMBH (DE) | 2002-12-19 | — | — | WO | disclosed |
| US-6441013-B1 | 5-HT6 RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS | MERCK PATENT GMBH (DE) | 2002-08-27 | — | — | US | disclosed |