SCHEMBL376644

SCHEMBL376644

O=Cc1nc2ccccc2[nH]1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.59
NPC1 O15118 10/20 0.59
RAB9A P51151 10/20 0.59
KDM4E B2RXH2 9/20 0.59
SMN1; SMN2 Q16637 6/20 0.59
MEN1 O00255 6/20 0.59
KMT2A Q03164 6/20 0.59
HPGD P15428 6/20 0.59
PKM P14618 4/20 0.59
HSP90AA1 P07900 1/20 0.59
TP53 P04637 2/20 0.54
NPSR1 Q6W5P4 2/20 0.54
HSD17B10 Q99714 2/20 0.54
ABCB11 O95342 1/20 0.54
GAA P10253 6/20 0.53
MAPT P10636 5/20 0.53
LMNA P02545 4/20 0.53
HTT P42858 4/20 0.53
GLA P06280 2/20 0.53
NFKB1 P19838 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29641181 1.00 ALDH1A1 (0.59) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL1086985 0.83 ALDH1A1 (0.81) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL1086983 0.83 ALDH1A1 (0.81) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL29539476 0.83 ALDH1A1 (0.81) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL19119423 0.83 ALDH1A1 (0.63) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL5572508 0.81 NPC1 (0.76) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL5572505 0.81 NPC1 (0.76) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL18422383 0.79 ALDH1A1 (0.59) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL718647 0.79 ALDH1A1 (0.59) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL8661689 0.79 ALDH1A1 (0.59) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 544 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119612785-B Sterilization corrosion and scale inhibitor for oil and gas field and preparation method thereof 山东得顺源石油科技有限公司 2025-04-18 CN claimed
CN-119612785-A Sterilization corrosion and scale inhibitor for oil and gas field and preparation method thereof 山东得顺源石油科技有限公司 2025-03-14 CN claimed
CN-118271370-B Aluminum ion near infrared fluorescent probe based on ruthenium (II) complex and preparation method and application thereof 潍坊科技学院 2024-08-02 CN claimed
CN-116239585-B Acylhydrazone organic corrosion inhibitor, preparation method and application thereof in epoxy paint 洛阳船舶材料研究所(中国船舶集团有限公司第七二五研究所) 2024-07-26 CN claimed
CN-118271370-A Aluminum ion near infrared fluorescent probe based on ruthenium (II) complex and preparation method and application thereof 潍坊科技学院 2024-07-02 CN claimed
CN-118108349-A Dirt preventive agent and preparation method and application thereof 杭州尚善若水环保科技有限公司 2024-05-31 CN claimed
CN-117756678-A Alpha-aminocarbonyl compound and preparation method and application thereof 成都大学 2024-03-26 CN claimed
CN-117209488-A Alkaloid barakacin derivative, synthesis thereof and application thereof in prevention and treatment of plant virus and germ diseases 天津师范大学 2023-12-12 CN claimed
CN-116282601-B Dirt preventive agent and preparation method and application thereof 杭州尚善若水环保科技有限公司 2023-09-01 CN claimed
CN-116239585-A Acylhydrazone organic corrosion inhibitor, preparation method and application thereof in epoxy paint 洛阳船舶材料研究所(中国船舶集团有限公司第七二五研究所) 2023-06-09 CN claimed
CN-103476768-B 6, 5-heterocyclic propargyl alcohol compounds and uses thereof HOFFMANN LA ROCHE 2015-07-08 CN claimed
CN-101675927-A therapeutic molecules and methods-1 CORTICAL PTY LTD 2010-03-24 CN claimed
US-7459415-B1 Lubricant for thin film storage media SEAGATE TECHNOLOGY LLC (US) 2008-12-02 US claimed
WO-2008133344-A2 PIPERIDINE DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-11-06 WO claimed
US-20040142999-A1 Novel compounds and compositions as cathepsin inhibitors AVENTIS PHARMACEUTICALS INC. (US) 2004-07-22 US claimed
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 EP claimed
US-20030138670-A1 Lubricant for thin film storage media SEAGATE TECHNOLOGY LLC 2003-07-24 US claimed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 WO claimed
US-20020026053-A1 Novel 3-(substituted) -2- indolinones compounds and use thereof as inhibitors of protein kinase activity TANG PENG CHO (US) 2002-02-28 US claimed
US-20010007033-A1 Novel 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity SUGEN, INC. 2001-07-05 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020026053-A1 Novel 3-(substituted) -2- indolinones compounds and use thereof as inhibitors of protein kinase activity MAP3K20, SBK3, MAP4K2 ALDH1A1 1624/4885NPC1 3279/4885RAB9A 1353/4885
US-20040142999-A1 Novel compounds and compositions as cathepsin inhibitors CTSS, CTSB, CTSE ALDH1A1 4046/4885NPC1 37/4885RAB9A 512/4885
US-20010007033-A1 Novel 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity SBK3, MAP4K2, MAP3K20 ALDH1A1 1608/4885NPC1 3340/4885RAB9A 1317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.