Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21198154 | 0.89 | NISCH (0.46) | CHRNB4CHRNA3CHRNB2CHRNA4POLB | |
| SCHEMBL9255239 | 0.82 | DRD2 (0.49) | RPS6KB2CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL11491200 | 0.81 | TSHR (0.57) | RPS6KB2POLBNISCHMAPTSMN1; SMN2 | |
| SCHEMBL1519311 | 0.81 | L3MBTL1 (0.49) | RPS6KB2POLBNPC1HTTALDH1A1 | |
| SCHEMBL20612385 | 0.81 | RPS6KB2 (0.46) | RPS6KB2POLBMAPTSMN1; SMN2NPC1 | |
| SCHEMBL1519098 | 0.81 | RAB9A (0.49) | RPS6KB2POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1519446 | 0.81 | RPS6KB2 (0.46) | RPS6KB2POLBMAPTSMN1; SMN2NPC1 | |
| SCHEMBL9412114 | 0.78 | KDM4E (0.53) | RPS6KB2POLBMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL229498 | 0.78 | HPGD (0.61) | POLBNISCHKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL1300333 | 0.78 | HPGD (0.61) | POLBNISCHKDM4ESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7842806-B2 | Pyridopyrimidone derivatives, preparation thereof, therapeutic use thereof | SANOFI-AVENTIS (FR) | 2010-11-30 | — | — | US | disclosed |
| US-20090048277-A1 | PYRIDOPYRIMIDONE DERIVATIVES, PREPARATION THEREOF, THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048277-A1 | PYRIDOPYRIMIDONE DERIVATIVES, PREPARATION THEREOF, THERAPEUTIC USE THEREOF | DPYD, TYMP, PDXK | RPS6KB2 3282/4885CHRNB4 4187/4885CHRNA3 3121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.