Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29751859 | 0.98 | SNCA (0.60) | SNCAHIF1ACYP19A1PLA2G1BATG4B | |
| SCHEMBL29392833 | 0.98 | SNCA (0.60) | SNCAHIF1ACYP19A1PLA2G1BATG4B | |
| Bromide SCHEMBL1503289 | 0.96 | SNCA (0.61) | SNCAHIF1ACYP19A1PLA2G1BATG4B | |
| Iodide SCHEMBL5462695 | 0.96 | SNCA (0.58) | SNCAHIF1ACYP19A1PLA2G1BATG4B | |
| SCHEMBL8376764 | 0.90 | SNCA (0.53) | SNCAHIF1ACYP19A1PLA2G1BATG4B | |
| SCHEMBL8375928 | 0.90 | SNCA (0.53) | SNCAHIF1ACYP19A1PLA2G1BATG4B | |
| SCHEMBL8605747 | 0.90 | SNCA (0.53) | SNCAHIF1ACYP19A1PLA2G1BATG4B | |
| Hydrochloric Acid SCHEMBL2446696 | 0.89 | SNCA (0.69) | SNCAHIF1AALDH1A1CYP3A4EPHX1 | |
| Iodide SCHEMBL9321342 | 0.84 | SNCA (0.69) | SNCAHIF1AALDH1A1CYP3A4EPHX1 | |
| Bromide SCHEMBL39844 | 0.84 | SNCA (0.73) | SNCAHIF1AALDH1A1CYP3A4EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 163 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111004239-B | Preparation method of ibrutinib precursor | 上海柏狮生物科技有限公司 | 2022-09-13 | — | — | CN | claimed |
| CN-111004239-A | Preparation method of ibrutinib precursor | 上海柏狮生物科技有限公司 | 2020-04-14 | — | — | CN | claimed |
| EP-4695271-A2 | A CYCLIC PEPTIDE FOR TRAPPING INTERLEUKIN-1 BETA | Merck Sharp & Dohme LLC (US) | 2026-02-18 | — | — | EP | disclosed |
| WO-2024258943-A1 | METHODS OF USING CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA | MERCK SHARP & DOHME LLC (US) | 2024-12-19 | — | — | WO | disclosed |
| WO-2024215820-A2 | A CYCLIC PEPTIDE FOR TRAPPING INTERLEUKIN-1 BETA | MERCK SHARP & DOHME LLC (US) | 2024-10-17 | — | — | WO | disclosed |
| CN-111004239-B | Preparation method of ibrutinib precursor | 上海柏狮生物科技有限公司 | 2022-09-13 | — | — | CN | disclosed |
| US-10928728-B2 | Photoactivable nitrogen bases | BASF SE (DE) | 2021-02-23 | — | — | US | disclosed |
| US-10913733-B2 | Substituted piperidines thiazolyl acetamides as glycosidase inhibitors and uses thereof | ALECTOS THERAPEUTICS INC. (CA) | 2021-02-09 | — | — | US | disclosed |
| US-20210033972-A1 | PHOTOACTIVABLE NITROGEN BASES | BASF SE (DE) | 2021-02-04 | — | — | US | disclosed |
| EP-3389658-B1 | GLYCOSIDASE INHIBITORS AND USES THEREOF | MERCK SHARP & DOHME (US) | 2020-11-25 | — | — | EP | disclosed |
| CN-111004239-A | Preparation method of ibrutinib precursor | 上海柏狮生物科技有限公司 | 2020-04-14 | — | — | CN | disclosed |
| US-4866086-A | PHENYLTRIAZOLYL OLEFINIC AROMATASE INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-09-12 | — | — | US | disclosed |
| EP-0311955-A2 | Bicyclic peroxide | F. HOFFMANN-LA ROCHE AG (CH) | 1989-04-19 | — | — | EP | disclosed |
| US-4806685-A | EXERTS VARIOUS EFFECTS ON ENDOCRINOUS SYSTEM OF RATS; INHIBITS GROWTH OF MAMMARY TUMORS | GYOGYSZERKUTATO INTEEZET/PHARMACEUTICAL RESEARCH INSTITUTE (HU) | 1989-02-21 | — | — | US | disclosed |
| EP-0299683-A2 | Heterocyclic olefinic compounds and their use as aromatase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-01-18 | — | — | EP | disclosed |
| US-4684731-A | NEUROLEPTIC, ANTIEMETIC, ANALGESIC | HOFFMANN-LA ROCHE INC. (US) | 1987-08-04 | — | — | US | disclosed |
| EP-0037990-B1 | PHENYL QUINOLIZIDINES, CORRESPONDING PHARMACEUTICAL PREPARATIONS, THE PREPARATION OF THE ACTIVE COMPOUNDS AND CORRESPONDING STARTING COMPOUNDS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-12-05 | — | — | EP | disclosed |
| US-4391978-A | NEUROLEPTIC AGENTS, ANTIEMETICS, ANALGESICS | HOFFMANN-LA ROCHE INC. (US) | 1983-07-05 | — | — | US | disclosed |
| US-4316905-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |
| EP-0037990-A1 | Phenyl quinolizidines, corresponding pharmaceutical preparations, the preparation of the active compounds and corresponding starting compounds | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-10-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210033972-A1 | PHOTOACTIVABLE NITROGEN BASES | CBR1, ARNT, NR0B1 | SNCA 2054/4885HIF1A 1258/4885CYP19A1 42/4885 |
| US-10928728-B2 | Photoactivable nitrogen bases | CBR1, NR0B1, NR0B2 | SNCA 1887/4885HIF1A 1136/4885CYP19A1 58/4885 |
| US-10913733-B2 | Substituted piperidines thiazolyl acetamides as glycosidase inhibitors and uses thereof | OGA, ENGASE, GAA | SNCA 2723/4885HIF1A 1124/4885CYP19A1 2798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.