Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | RARB | P10826 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480448 | 0.89 | RARB (0.54) | ALDH1A1RARBTP53TSHRKMT2A | |
| SCHEMBL3455668 | 0.82 | PLA2G10 (0.48) | ALDH1A1TSHRKMT2AMEN1MAPT | |
| SCHEMBL4946030 | 0.82 | KMT2A (0.55) | ALDH1A1KMT2AMEN1MAPTNR1H2 | |
| SCHEMBL11580792 | 0.82 | MEN1 (0.44) | ALDH1A1KMT2AMEN1MAPTNR1H2 | |
| SCHEMBL4968695 | 0.82 | ALDH1A1 (0.52) | ALDH1A1RARBTP53TSHRKMT2A | |
| Terephthalic Acid SCHEMBL4612225 | 0.80 | TSHR (0.67) | ALDH1A1RARBTP53TSHRKMT2A | |
| SCHEMBL70166 | 0.80 | TSHR (0.67) | ALDH1A1RARBTP53TSHRKMT2A | |
| SCHEMBL31747387 | 0.80 | ALDH1A1 (0.50) | ALDH1A1RARBTP53TSHRKMT2A | |
| SCHEMBL8764230 | 0.80 | MEN1 (0.64) | ALDH1A1TSHRKMT2AMEN1NR1H2 | |
| SCHEMBL211305 | 0.79 | ALDH1A1 (0.54) | ALDH1A1RARBTP53TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102123987-A | Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds | GILEAD COLORADO INC | 2011-07-13 | — | — | CN | disclosed |
| US-7851658-B2 | Palladium-catalyzed carbon-carbon bond forming reactions | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-12-14 | — | — | US | disclosed |
| WO-2007008226-A9 | PALLADIUM-CATALYZED CARBON-CARBON BOND FORMING REACTIONS | HARVARD COLLEGE (US) | 2007-05-24 | — | — | WO | disclosed |
| US-20070066851-A1 | Palladium-catalyzed carbon-carbon bond forming reactions | NAVY, SECRETARY OF THE UNITED STATES OF AMERICA | 2007-03-22 | — | — | US | disclosed |
| WO-2007008226-A2 | PALLADIUM-CATALYZED CARBON-CARBON BOND FORMING REACTIONS | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-01-18 | — | — | WO | disclosed |
| US-20050075345-A1 | Novel inhibitor compounds specific of secreted non-pancreatic human a<sb>2</sb>phospholipase of group II | YANG JI CHEMICAL COMPANY LTD. (KR) | 2005-04-07 | — | — | US | disclosed |
| US-5145854-A | 1-formyl-5,8,10-trideazafolates | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 1992-09-08 | — | — | US | disclosed |
| US-4105653-A | HETERYL-AZO-PHENYL DISPERSE DYESTUFFS CONTAINING A Z-SUBSTITUTED BENZOLYLOXYALKYL RADICAL, WHEREIN Z IS 2-CYANOVINYL 2-CYANOETHYL OR 2-CHLORO-2-CYANOETHYL | PRODUITS CHIMIQUES UGINE KUHLMANN (FR) | 1978-08-08 | — | — | US | disclosed |
| US-3987027-A | DISPERSE AZO DYES | PRODUITS CHIMIQUES UGINE KUHLMANN (FR) | 1976-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066851-A1 | Palladium-catalyzed carbon-carbon bond forming reactions | APEX1, PCNA, DNMT3A | ALDH1A1 564/4885RARB 3349/4885TP53 2229/4885 |
| US-20050075345-A1 | Novel inhibitor compounds specific of secreted non-pancreatic human a<sb>2</sb>phospholipase of group II | AMY2A, PNLIP, IAPP | ALDH1A1 3782/4885RARB 2571/4885TP53 3676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.