Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | OTC | P00480 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL632876 | 0.91 | KDM4E (0.46) | KDM4EMAPK1HIF1ATGFBR1PAOX | |
| Phosphoric Acid SCHEMBL3702994 | 0.90 | MMP2 (0.42) | CA12CA1CA2CA9MMP2 | |
| SCHEMBL16309325 | 0.89 | KDM4E (0.44) | KDM4EMAPK1HIF1ATGFBR1PAOX | |
| Phosphoric Acid SCHEMBL3771023 | 0.87 | EPHX1 (0.52) | MMP2FNTAFNTB | |
| Phosphoric Acid SCHEMBL3463649 | 0.87 | EPHX1 (0.52) | MMP2FNTAFNTB | |
| Phosphoric Acid SCHEMBL9949958 | 0.87 | PAOX (0.53) | CA12CA1CA2CA9MMP2 | |
| SCHEMBL907569 | 0.86 | KDM4E (0.52) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL432614 | 0.86 | S1PR2 (0.43) | CA12CA1CA2CA9MMP2 | |
| SCHEMBL24099895 | 0.84 | KDM4E (0.41) | KDM4EMAPK1HIF1ATGFBR1PAOX | |
| SCHEMBL20319875 | 0.84 | KDM4E (0.58) | KDM4EMAPK1HIF1APAOXADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851515-B2 | Hydrolysis-stable self-etching single-component dental adhesive | IVOCLAR VIVADENT AG (LI) | 2010-12-14 | — | — | US | claimed |
| US-7851515-B2 | Hydrolysis-stable self-etching single-component dental adhesive | IVOCLAR VIVADENT AG (LI) | 2010-12-14 | — | — | US | disclosed |
| US-20060130701-A1 | Hydrolysis-stable self-etching single-component dental adhesive | IVOCLAR VIVADENT AG (LI) | 2006-06-22 | — | — | US | disclosed |