Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28466349 | 0.86 | ESR1 (0.36) | HTTLMNAL3MBTL1NPSR1ESR1 | |
| SCHEMBL3477103 | 0.77 | ADRB2 (0.36) | HTTL3MBTL1ESR1ESR2MEN1 | |
| SCHEMBL27715205 | 0.73 | NPSR1 (0.49) | HTTLMNAL3MBTL1NPSR1 | |
| SCHEMBL1399020 | 0.65 | HTT (0.43) | HTTLMNAMEN1KMT2AADRB2 | |
| SCHEMBL3717417 | 0.65 | ADRB2 (0.58) | HTTADRB2ALDH1A1SMN1; SMN2HSD11B1 | |
| SCHEMBL28647728 | 0.65 | ADRB2 (0.44) | HTTMEN1KMT2ATSHRADRB2 | |
| SCHEMBL20630554 | 0.64 | LMNA (0.42) | HTTLMNAL3MBTL1NPSR1MEN1 | |
| SCHEMBL21895900 | 0.64 | LMNA (0.42) | HTTLMNAL3MBTL1NPSR1MEN1 | |
| SCHEMBL3618445 | 0.64 | ADRB2 (0.65) | HTTLMNAMEN1KMT2ATSHR | |
| SCHEMBL19028118 | 0.63 | ALDH1A1 (0.39) | HTTLMNANPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765778-B1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2012-01-25 | — | — | EP | disclosed |