Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 5/20 | 0.51 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.51 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.51 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.51 |
| ▸ | TSPO | P30536 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | SGPL1 | O95470 | 4/20 | 0.47 |
| ▸ | BLM | P54132 | 3/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3777505 | 0.87 | S1PR1 (0.68) | LPAR3LPAR1LPAR2S1PR1S1PR4 | |
| SCHEMBL19005913 | 0.82 | S1PR1 (0.52) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL3763587 | 0.81 | S1PR1 (0.76) | LPAR3LPAR1LPAR2S1PR1S1PR4 | |
| SCHEMBL3772063 | 0.79 | SPHK2 (0.62) | LPAR3LPAR1LPAR2S1PR1S1PR4 | |
| SCHEMBL2854224 | 0.77 | S1PR1 (0.46) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL15235841 | 0.77 | SPHK2 (0.61) | ALDH1A1BLMMEN1KMT2AMAPT | |
| SCHEMBL1512942 | 0.77 | SPHK2 (0.61) | ALDH1A1BLMMEN1KMT2AMAPT | |
| SCHEMBL22986833 | 0.77 | SPHK2 (0.61) | ALDH1A1BLMMEN1KMT2AMAPT | |
| Phosphoric Acid SCHEMBL6665386 | 0.77 | MAPT (0.54) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| Iodide SCHEMBL5689882 | 0.76 | SPHK2 (0.59) | ALDH1A1BLMMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190183910-A1 | ENHANCING DNA REPAIR AND PREVENTING AGING AND ITS CONSEQUENCES IN REPRODUCTIVE AND OTHER CELLS | OKTAY, KUTLUK (US) | 2019-06-20 | — | — | US | claimed |
| US-5877167-A | Method for inhibition of cell motility by sphingosine-1-phosphate and its derivatives | OTSUKA AMERICA PHARMACEUTICAL, INC. (US) | 1999-03-02 | — | — | US | claimed |
| EP-0671917-A4 | METHOD FOR INHIBITION OF CELL MOTILITY BY SPHINGOSINE-1-PHOSPHATE, ITS DERIVATIVES AND MIMETICS AND METHOD OF SYNTHESIZING SPHINGOSINE-1-PHOSPHATE AND ITS DERIVATIVES. | BIOMEMBRANE INST (US) | 1997-06-18 | — | — | EP | claimed |
| EP-0671917-A1 | METHOD FOR INHIBITION OF CELL MOTILITY BY SPHINGOSINE-1-PHOSPHATE, ITS DERIVATIVES AND MIMETICS AND METHOD OF SYNTHESIZING SPHINGOSINE-1-PHOSPHATE AND ITS DERIVATIVES | ONCOMEMBRANE, INC. (US) | 1995-09-20 | — | — | EP | claimed |
| US-5260288-A | Administering an inflammation inhibitory amount | THE BIOMEMBRANE INSTITUTE (US) | 1993-11-09 | — | — | US | claimed |
| WO-1993019760-A1 | METHOD FOR INHIBITION OF CELL MOTILITY BY SPHINGOSINE-1-PHOSPHATE, ITS DERIVATIVES AND MIMETICS AND METHOD OF SYNTHESIZING SPHINGOSINE-1-PHOSPHATE AND ITS DERIVATIVES | THE BIOMEMBRANE INSTITUTE (US) | 1993-10-14 | — | — | WO | claimed |
| US-20190183910-A1 | ENHANCING DNA REPAIR AND PREVENTING AGING AND ITS CONSEQUENCES IN REPRODUCTIVE AND OTHER CELLS | OKTAY, KUTLUK (US) | 2019-06-20 | — | — | US | disclosed |
| WO-2017223152-A1 | ENHANCING DNA REPAIR AND PREVENTING AGING AND ITS CONSEQUENCES IN REPRODUCTIVE AND OTHER CELLS | NEW YORK MEDICAL COLLEGE (US) | 2017-12-28 | — | — | WO | disclosed |
| US-7850984-B2 | Protection of the female reproductive system from natural and artificial insults | THE GENERAL HOSPITAL CORPORATION (US) | 2010-12-14 | — | — | US | disclosed |
| US-20070157331-A1 | Protection of female reproductive system from natural and artifical insults | MASSACHUSETTS GENERAL HOSPITAL, PARTNERS HEALTHCARE RESEARCH VENTURES & LICENSING (US) | 2007-07-05 | — | — | US | disclosed |
| US-7195775-B1 | Protection of the female reproductive system from natural and artificial insults | THE GENERAL HOSPITAL CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| WO-2004014271-A1 | PROTECTION OF THE FEMALE REPRODUCTIVE SYSTEM FROM NATURAL AND ARTIFICIAL INSULTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2004-02-19 | — | — | WO | disclosed |
| US-20030157086-A1 | Protection of the female reproductive system from natural and artificial insults | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2003-08-21 | — | — | US | disclosed |
| US-5877167-A | Method for inhibition of cell motility by sphingosine-1-phosphate and its derivatives | OTSUKA AMERICA PHARMACEUTICAL, INC. (US) | 1999-03-02 | — | — | US | disclosed |
| US-5663404-A | ANTITUMOR AGENTS; ANTIINFLAMMATORY AGENTS | ONCOMEMBRANE (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0671917-A4 | METHOD FOR INHIBITION OF CELL MOTILITY BY SPHINGOSINE-1-PHOSPHATE, ITS DERIVATIVES AND MIMETICS AND METHOD OF SYNTHESIZING SPHINGOSINE-1-PHOSPHATE AND ITS DERIVATIVES. | BIOMEMBRANE INST (US) | 1997-06-18 | — | — | EP | disclosed |
| EP-0671917-A1 | METHOD FOR INHIBITION OF CELL MOTILITY BY SPHINGOSINE-1-PHOSPHATE, ITS DERIVATIVES AND MIMETICS AND METHOD OF SYNTHESIZING SPHINGOSINE-1-PHOSPHATE AND ITS DERIVATIVES | ONCOMEMBRANE, INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| US-5391800-A | Protecting hydroxyl groups of sphingosine, deprotecting C1, phosphorylating, deprotecting C3; free of L-threo isomer | THE BIOMEMBRANE INSTITUTE (US) | 1995-02-21 | — | — | US | disclosed |
| US-5260288-A | Administering an inflammation inhibitory amount | THE BIOMEMBRANE INSTITUTE (US) | 1993-11-09 | — | — | US | disclosed |
| WO-1993019760-A1 | METHOD FOR INHIBITION OF CELL MOTILITY BY SPHINGOSINE-1-PHOSPHATE, ITS DERIVATIVES AND MIMETICS AND METHOD OF SYNTHESIZING SPHINGOSINE-1-PHOSPHATE AND ITS DERIVATIVES | THE BIOMEMBRANE INSTITUTE (US) | 1993-10-14 | — | — | WO | disclosed |