Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | CASP1 | P29466 | 2/20 | 0.58 |
| ▸ | CASP7 | P55210 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 5/20 | 0.58 |
| ▸ | MGAM | O43451 | 5/20 | 0.58 |
| ▸ | SI | P14410 | 3/20 | 0.58 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.57 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28305790 | 0.84 | ALDH1A1 (0.59) | ALDH1A1HPGDHSD17B10CYP3A4CASP1 | |
| SCHEMBL536984 | 0.80 | ALDH1A1 (0.72) | ALDH1A1HPGDHSD17B10CYP3A4CASP1 | |
| SCHEMBL3778782 | 0.74 | ALDH1A1 (0.64) | ALDH1A1HPGDHSD17B10CYP3A4CASP1 | |
| SCHEMBL30542658 | 0.74 | MGAM (1.00) | ALDH1A1HPGDHSD17B10CYP3A4CASP1 | |
| SCHEMBL9838561 | 0.74 | MGAM (1.00) | ALDH1A1HPGDHSD17B10CYP3A4CASP1 | |
| 5,7-Dihydroxy-4-Methylcoumarin SCHEMBL403833 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HPGDHSD17B10CYP3A4CASP1 | |
| 5,7-Dihydroxy-4-Methylcoumarin SCHEMBL29431030 | 0.74 | ALDH1A1 (1.00) | ALDH1A1HPGDHSD17B10CYP3A4CASP1 | |
| SCHEMBL307508 | 0.73 | HSD17B3 (1.00) | ALDH1A1HPGDHSD17B10CASP1CASP7 | |
| SCHEMBL29648420 | 0.73 | HSD17B3 (1.00) | ALDH1A1HPGDHSD17B10CASP1CASP7 | |
| SCHEMBL504349 | 0.73 | MGAM (0.74) | ALDH1A1HPGDHSD17B10CYP3A4CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101896492-B | Tetriacyclodipyranyl coumarins and the anti-HIV and anti-tuberculosis uses thereof | INST OF MATARIA MEDICA CHINESE | 2015-05-06 | — | — | CN | disclosed |
| EP-2216335-B1 | TETRACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF | INST MATERIA MEDICA CAMS (CN) | 2014-03-12 | — | — | EP | disclosed |
| EP-2216335-B1 | TETRACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF | INST MATERIA MEDICA CAMS (CN) | 2014-03-12 | — | — | EP | disclosed |
| CN-101100470-B | Tetracyclic bispyranyl coumarin compounds | INST MATERIA MEDICA CAMS | 2013-02-13 | — | — | CN | disclosed |
| US-20100324067-A1 | TETRACYCLIC DIPYRANO-COUMARIN COMPOUNDS WITH ANTI-HIV AND ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITIES | INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2010-12-23 | — | — | US | disclosed |
| US-20100324067-A1 | TETRACYCLIC DIPYRANO-COUMARIN COMPOUNDS WITH ANTI-HIV AND ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITIES | INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2010-12-23 | — | — | US | disclosed |
| US-20100324067-A1 | TETRACYCLIC DIPYRANO-COUMARIN COMPOUNDS WITH ANTI-HIV AND ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITIES | INSTITUTE OF MATARIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2010-12-23 | — | — | US | disclosed |
| CN-101896492-A | Tetriacyclodipyranyl coumarins and the anti-HIV and anti-tuberculosis uses thereof | INST OF MATARIA MEDICA CHINESE | 2010-11-24 | — | — | CN | disclosed |
| EP-2216335-A1 | TETRIACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF | Institute of Mataria Medica, Chinese Academy of Medical Sciences (CN) | 2010-08-11 | — | — | EP | disclosed |
| EP-2216335-A1 | TETRIACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF | Institute of Mataria Medica, Chinese Academy of Medical Sciences (CN) | 2010-08-11 | — | — | EP | disclosed |
| US-20020013478-A1 | Calanolide analogues and methods of their use | SARAWAK MEDICHEM PHARMACEUTICALS,INC. | 2002-01-31 | — | — | US | disclosed |
| US-20010027209-A1 | Method and composition for treating and preventing mycobacterium infections | SARAWAK MEDICHEM PHARMACEUTICALS, INC. | 2001-10-04 | — | — | US | disclosed |
| US-6277879-B1 | VIRICIDES | SARAWAK MEDICHEM PHARMACEUTICALS, INC. | 2001-08-21 | — | — | US | disclosed |
| US-6268393-B1 | CALANOLIDES AND ANALOGUES THEREOF | SARAWAK MEDICHEM PHARMACEUTICALS | 2001-07-31 | — | — | US | disclosed |
| US-5981770-A | HIV REVERSE TRANSCRIPTASE INHIBITOR, VIRICIDE | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 1999-11-09 | — | — | US | disclosed |
| US-5977385-A | VIRICIDES | SARAWAK MEDICHEM PHARMACEUTICALS (US) | 1999-11-02 | — | — | US | disclosed |
| US-5892060-A | REVERSE TRANSCRIPTASE INHIBITOR; AIDS THERAPY | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 1999-04-06 | — | — | US | disclosed |
| US-5872264-A | BENZO(1,2-B:5,6--B?)TRIPYRAN-2,12-DIONES | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 1999-02-16 | — | — | US | disclosed |
| US-5859050-A | ADMINISTERING TO PREVENT OR TREAT A VIRAL INFECTION | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1998038193-A1 | METHOD FOR THE PREPARATION OF (+)-CALANOLIDE A AND ANALOGUES THEREOF | MEDICHEM RESEARCH, INC. (US) | 1998-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324067-A1 | TETRACYCLIC DIPYRANO-COUMARIN COMPOUNDS WITH ANTI-HIV AND ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITIES | TBCB, TBC1D15, TBC1D5 | ALDH1A1 482/4885HPGD 1602/4885HSD17B10 159/4885 |
| US-20010027209-A1 | Method and composition for treating and preventing mycobacterium infections | CYP51A1, DHCR7, CYP27A1 | ALDH1A1 2628/4885HPGD 708/4885HSD17B10 125/4885 |
| US-20020013478-A1 | Calanolide analogues and methods of their use | HAVCR2, ZC3HAV1, CYP51A1 | ALDH1A1 3786/4885HPGD 2567/4885HSD17B10 659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.