Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.72 |
| ▸ | HPGD | P15428 | 4/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | CASP7 | P55210 | 2/20 | 0.72 |
| ▸ | CASP1 | P29466 | 1/20 | 0.72 |
| ▸ | CA9 | Q16790 | 1/20 | 0.72 |
| ▸ | MGAM | O43451 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 4/20 | 0.67 |
| ▸ | SI | P14410 | 3/20 | 0.67 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.67 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | MAOA | P21397 | 6/20 | 0.55 |
| ▸ | PIM1 | P11309 | 4/20 | 0.55 |
| ▸ | FASN | P49327 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5,7-Dihydroxy-4-Methylcoumarin SCHEMBL403833 | 0.84 | ALDH1A1 (1.00) | ALDH1A1CYP3A4HPGDHSD17B10TSHR | |
| SCHEMBL5118377 | 0.84 | ALDH1A1 (0.86) | ALDH1A1CYP3A4HPGDHSD17B10TSHR | |
| 5,7-Dihydroxy-4-Methylcoumarin SCHEMBL29431030 | 0.84 | ALDH1A1 (1.00) | ALDH1A1CYP3A4HPGDHSD17B10TSHR | |
| 5,7-Dihydroxy-4-Methylcoumarin SCHEMBL4395631 | 0.83 | ALDH1A1 (0.96) | ALDH1A1CYP3A4HPGDHSD17B10TSHR | |
| SCHEMBL3778775 | 0.81 | ALDH1A1 (0.75) | ALDH1A1CYP3A4HPGDHSD17B10TSHR | |
| SCHEMBL30542658 | 0.80 | MGAM (1.00) | ALDH1A1CYP3A4HPGDHSD17B10TSHR | |
| SCHEMBL9838561 | 0.80 | MGAM (1.00) | ALDH1A1CYP3A4HPGDHSD17B10TSHR | |
| SCHEMBL27731527 | 0.80 | ALDH1A1 (0.64) | ALDH1A1CYP3A4HPGDHSD17B10TSHR | |
| SCHEMBL13016592 | 0.80 | ALDH1A1 (0.64) | ALDH1A1CYP3A4HPGDHSD17B10TSHR | |
| SCHEMBL3772661 | 0.80 | ALDH1A1 (0.58) | ALDH1A1CYP3A4HPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3277692-B1 | COUMARIN DERIVATIVE AS ANTIVIRAL AGENT, PHARMACEUTICAL COMPOSITION THEREOF, ITS PREPARATION AND USE | I NOVA MEDICINSKA ISTRAZIVANJA D O O (HR) | 2019-09-11 | — | — | EP | claimed |
| US-10266545-B2 | Coumarin derivative as antiviral agent, pharmaceutical composition thereof, its preparation and use | I-NOVA MEDICINSKA ISTRAZIVANJA D.O.O. (HR) | 2019-04-23 | — | — | US | claimed |
| US-20180072752-A1 | COUMARIN DERIVATIVE AS ANTIVIRAL AGENT, PHARMACEUTICAL COMPOSITION THEREOF, ITS PREPARATION AND USE | I-NOVA MEDICINSKA ISTRAZIVANJA D.O.O. (HR) | 2018-03-15 | — | — | US | claimed |
| CN-101448395-A | Compositions and methods for increasing the value of plant products, enhancing their commercial quality, enhancing their resistance to external agents and increasing their polyphenol content | ANTONI LESCHOT SANHUEZA ANDRES (CL) | 2009-06-03 | — | — | CN | claimed |
| US-20070232495-A1 | Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof | NAPPA ALVARO O | 2007-10-04 | — | — | US | claimed |
| EP-0906909-B1 | Novel hydroxy and polyhydroxy derivatives of coumarin, peperation thereof and antiviral action thereof | PLIVA PHARM & CHEM WORKS (HR) | 2002-01-30 | — | — | EP | claimed |
| US-6291518-B1 | Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof | PLIVA FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA, DIONICKO DRUSTVO (HR) | 2001-09-18 | — | — | US | claimed |
| US-6100409-A | Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof | PLIVA FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA DIONICKO DRUSTVO (HR) | 2000-08-08 | — | — | US | claimed |
| EP-0906909-A1 | Novel hydroxy and polyhydroxy derivatives of coumarin, peperation thereof and antiviral action thereof | PLIVA farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo (HR) | 1999-04-07 | — | — | EP | claimed |
| US-11324827-B2 | Multifunctionalized polyethylene glycol derivative and preparation method therefor | XIAMEN SINOPEG BIOTECH CO., LTD. (CN) | 2022-05-10 | — | — | US | disclosed |
| CN-110643032-B | Eight-arm polyethylene glycol, preparation method, functionalized derivative and modified biologically-relevant substance | 厦门赛诺邦格生物科技股份有限公司 | 2022-01-28 | — | — | CN | disclosed |
| CN-107382944-B | Coumarin gossypol derivatives with anti-tumor activity and synthesis method thereof | 陕西盘龙医药股份有限公司 | 2020-05-29 | — | — | CN | disclosed |
| US-10660969-B2 | Eight-arm polyethylene glycol derivative, production method therefor, and modified bio-related substance thereof | XIAMEN SINOPEG BIOTECH CO., LTD. (CN) | 2020-05-26 | — | — | US | disclosed |
| CN-110643032-A | Eight-arm polyethylene glycol, preparation method, functionalized derivative and modified biologically-relevant substance | 厦门赛诺邦格生物科技股份有限公司 | 2020-01-03 | — | — | CN | disclosed |
| JP-2001089467-A | NEW HYDROXYCOUMARIN DERIVATIVE AND METHOD FOR PRODUCING THE SAME | PLIVA FARMACEUT KEMIJSKA PREHRAMBENA I KOZMET IND DIONICKO DRUSTVO | 2001-04-03 | — | — | JP | disclosed |
| US-6100409-A | Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof | PLIVA FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA DIONICKO DRUSTVO (HR) | 2000-08-08 | — | — | US | disclosed |
| US-6100409-A | Hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof | PLIVA FARMACEUTSKA, KEMIJSKA, PREHRAMBENA I KOZMETICKA INDUSTRIJA DIONICKO DRUSTVO (HR) | 2000-08-08 | — | — | US | disclosed |
| CN-1220263-A | Novel hydroxy and polyhydroxy derivatives of coumarin, preparation thereof and antiviral action thereof | PLIVA PHARM & CHEM WORKS (HR) | 1999-06-23 | — | — | CN | disclosed |
| EP-0906909-A1 | Novel hydroxy and polyhydroxy derivatives of coumarin, peperation thereof and antiviral action thereof | PLIVA farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo (HR) | 1999-04-07 | — | — | EP | disclosed |
| EP-0906909-A1 | Novel hydroxy and polyhydroxy derivatives of coumarin, peperation thereof and antiviral action thereof | PLIVA farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo (HR) | 1999-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10660969-B2 | Eight-arm polyethylene glycol derivative, production method therefor, and modified bio-related substance thereof | MRPL38, ALG8, COG8 | ALDH1A1 787/4885CYP3A4 1205/4885HPGD 2084/4885 |
| US-20070232495-A1 | Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof | C5, PNN, NQO1 | ALDH1A1 3137/4885CYP3A4 843/4885HPGD 955/4885 |
| US-20180072752-A1 | COUMARIN DERIVATIVE AS ANTIVIRAL AGENT, PHARMACEUTICAL COMPOSITION THEREOF, ITS PREPARATION AND USE | CYP3A7, MAVS, SARS1 | ALDH1A1 798/4885CYP3A4 6/4885HPGD 1237/4885 |
| US-10266545-B2 | Coumarin derivative as antiviral agent, pharmaceutical composition thereof, its preparation and use | CYP3A7, MAVS, SARS1 | ALDH1A1 798/4885CYP3A4 6/4885HPGD 1237/4885 |
| US-11324827-B2 | Multifunctionalized polyethylene glycol derivative and preparation method therefor | HDGF, F11, F12 | ALDH1A1 1582/4885CYP3A4 2743/4885HPGD 549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.