Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 4/20 | 0.50 |
| ▸ | PIM1 | P11309 | 3/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GABRP | O00591 | 1/20 | 0.50 |
| ▸ | GABRD | O14764 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TOP1 | P11387 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13149180 | 0.85 | PIM1 (0.53) | CHUKPIM1GABRA1GABRG2GABRB3 | |
| SCHEMBL13148311 | 0.82 | CHUK (0.50) | CHUKPIM1GABRA1GABRG2GABRB3 | |
| SCHEMBL13148102 | 0.79 | PDE10A (0.58) | CHUKPIM1GABRA1GABRG2GABRB3 | |
| SCHEMBL2598068 | 0.75 | MAPK14 (0.42) | PIM1KDM4EALDH1A1IDO1PDE10A | |
| SCHEMBL27075645 | 0.74 | CHUK (0.50) | CHUKPIM1GABRA1GABRG2GABRB3 | |
| SCHEMBL13148432 | 0.74 | TUBB4A (0.49) | CHUKPIM1GABRA1GABRG2GABRB3 | |
| SCHEMBL16486025 | 0.72 | ACHE (0.47) | CHUKPIM1GABRA1GABRG2GABRB3 | |
| SCHEMBL4819042 | 0.70 | CHUK (0.58) | CHUKPIM1GABRA1GABRG2GABRB3 | |
| SCHEMBL27075642 | 0.70 | CHUK (0.45) | CHUKPIM1GABRA1GABRG2GABRB3 | |
| Norharmane SCHEMBL25834 | 0.68 | CHUK (1.00) | CHUKPIM1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010115901-A1 | PYRROLOPYRIDINE THERAPEUTIC COMPOUNDS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010115901-A1 | PYRROLOPYRIDINE THERAPEUTIC COMPOUNDS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2010-10-14 | — | — | WO | disclosed |