Sugi Predict

Sugi Predict / Compounds / SCHEMBL377567

SCHEMBL377567

SCHEMBL377567

CC(=O)Oc1ccc(O)c(F)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP3A4 P08684 2/20 0.52
▸ LMNA P02545 3/20 0.48
▸ KDM4E B2RXH2 3/20 0.47
▸ ACHE P22303 2/20 0.46
▸ MAPT P10636 4/20 0.44
▸ POLB P06746 3/20 0.44
▸ PKM P14618 1/20 0.44
▸ CA12 O43570 2/20 0.44
▸ CA9 Q16790 2/20 0.44
▸ GLA P06280 1/20 0.44
▸ GAA P10253 1/20 0.44
▸ TDP1 Q9NUW8 1/20 0.44
▸ MEN1 O00255 1/20 0.43
▸ TTR P02766 1/20 0.43
▸ TP53 P04637 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ ELANE P08246 1/20 0.43
▸ FLT3 P36888 1/20 0.42
▸ MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24436689 0.85 CYP3A4 (0.56) CYP3A4LMNAKDM4EACHEMAPT
SCHEMBL823757 0.84 LMNA (0.52) CYP3A4LMNAKDM4EACHEMAPT
SCHEMBL31621879 0.84 LMNA (0.52) CYP3A4LMNAKDM4EACHEMAPT
SCHEMBL18309867 0.82 ELANE (0.47) CYP3A4LMNAKDM4EMAPTPOLB
SCHEMBL32667335 0.82 ELANE (0.47) CYP3A4LMNAKDM4EMAPTPOLB
SCHEMBL50809 0.82 CYP3A4 (0.62) CYP3A4LMNAKDM4EACHEMAPT
SCHEMBL1432110 0.81 ACHE (0.59) CYP3A4LMNAKDM4EACHEMAPT
SCHEMBL4311410 0.81 MEN1 (0.53) LMNAKDM4EMAPTPOLBMEN1
SCHEMBL19335493 0.80 ELANE (0.55) MAPTPOLBMEN1KMT2AELANE
SCHEMBL8576981 0.80 CYP3A4 (0.55) CYP3A4LMNAKDM4EACHEMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8287764-B2 Coated particles AKZO NOBEL N.V. (NL) 2012-10-16 — — US claimed
US-20110133128-A1 COATED PARTICLES AKZO NOBEL N.V. (NL) 2011-06-09 — — US claimed
EP-2303961-A1 COATED PARTICLES Akzo Nobel N.V. (NL) 2011-04-06 — — EP claimed
WO-2010010052-A1 COATED PARTICLES AKZO NOBEL N.V. (NL) 2010-01-28 — — WO claimed
CN-117858865-A CBL-B modulators and uses thereof 林伯士克莱奥公司 2024-04-09 — — CN disclosed
CN-117545748-A Benzimidazolyl GLP-1GPCR receptor agonists, pharmaceutical compositions comprising the same, and methods of use thereof 卡莫特医疗有限公司 2024-02-09 — — CN disclosed
US-20230210808-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2023-07-06 — — US disclosed
EP-4001336-A1 POLYURETHANE, POLYURETHANE PRODUCTION METHOD, CONDUCTIVE PASTE COMPOSITION, CONDUCTIVE WIRE, AND METHOD FOR PRODUCING CONDUCTIVE WIRE Shin-Etsu Chemical Co., Ltd. (JP) 2022-05-25 — — EP disclosed
US-20220157484-A1 POLYURETHANE, POLYURETHANE PRODUCTION METHOD, CONDUCTIVE PASTE COMPOSITION, CONDUCTIVE WIRE, AND METHOD FOR PRODUCING CONDUCTIVE WIRE SHIN-ETSU CHEMICAL CO., LTD. (JP) 2022-05-19 — — US disclosed
US-20190192475-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2019-06-27 — — US disclosed
US-20170304254-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS JANSSEN PHARMACEUTICA NV (DE) 2017-10-26 — — US disclosed
US-9724322-B2 4-(phenoxyalkyl)thio)-phenoxyacetic acids and analogs JANSSEN PHARMACEUTICA N.V. (BE) 2017-08-08 — — US disclosed
US-20050107469-A1 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs CYMABAY THERAPEUTICS, INC. 2005-05-19 — — US disclosed
WO-2005042478-A2 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS JANSSEN PHARMACEUTICA, N.V. (BE) 2005-05-12 — — WO disclosed
CN-1087934-C Use of phenalkylamines HOFFMANN LA ROCHE (CH) 2002-07-24 — — CN disclosed
CN-1288462-A Oxazolidinone combinatorial libraries, compositions and method of prepn. UPJOHN CO (US) 2001-03-21 — — CN disclosed
CN-1033031-C Modified gangliosides and functional derivatives thereof FIDIA SPA (IT) 1996-10-16 — — CN disclosed
CN-1051912-A Improved gangliosides and functional derivatives thereof FIDIA B P A (IT) 1991-06-05 — — CN disclosed
WO-1990002114-A1 THERAPEUTIC POLYAMINE-AMIDES NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1990-03-08 — — WO disclosed
WO-1990001875-A1 BIOCIDAL POLYAMINE-AMIDES NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1990-03-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190192475-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD CYP3A4 1163/4885LMNA 2274/4885KDM4E 843/4885
US-20230210808-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD CYP3A4 1163/4885LMNA 2274/4885KDM4E 843/4885
US-20110133128-A1 COATED PARTICLES CD63, CD44, S100A4 CYP3A4 3266/4885LMNA 1149/4885KDM4E 1041/4885
US-20170304254-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD CYP3A4 1163/4885LMNA 2274/4885KDM4E 843/4885
US-20050107469-A1 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs PPARA, PPARG, PPARD CYP3A4 1148/4885LMNA 2440/4885KDM4E 1023/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.