Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3012172 | 0.96 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL3011267 | 0.90 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL3016535 | 0.90 | LMNA (0.44) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL3013990 | 0.90 | L3MBTL1 (0.49) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL3653907 | 0.88 | KMT2A (0.48) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL3011026 | 0.87 | RAB9A (0.47) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL3016382 | 0.87 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL3020101 | 0.87 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL3648044 | 0.86 | MAPT (0.42) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL3008296 | 0.85 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188272-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV Remynd (BE) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009019295-A2 | PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-12 | — | — | WO | disclosed |